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Autolysosomal exocytosis of lipids protect neurons from ferroptosis

Isha Ralhan, Jinlan Chang, View ORCID ProfileMatthew J. Moulton, View ORCID ProfileLindsey D. Goodman, Nathanael Y.J. Lee, Greg Plummer, View ORCID ProfileH. Amalia Pasolli, View ORCID ProfileDoreen Matthies, View ORCID ProfileHugo J. Bellen, View ORCID ProfileMaria S. Ioannou
doi: https://doi.org/10.1101/2022.11.24.517842
Isha Ralhan
1Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada
2Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2R3, Canada
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Jinlan Chang
1Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada
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Matthew J. Moulton
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
4Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
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  • ORCID record for Matthew J. Moulton
Lindsey D. Goodman
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
4Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
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Nathanael Y.J. Lee
1Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada
2Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2R3, Canada
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Greg Plummer
5Faculty of Medicine & Dentistry Cell Imaging Core, University of Alberta, Edmonton, AB T6G 2R3, Canada
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H. Amalia Pasolli
6Electron Microscopy Resource Center, The Rockefeller University, New York, NY 10065, USA
7Janelia Research Campus, Howard Hughes Medical Institute, Ashburn VA 20147, USA
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  • ORCID record for H. Amalia Pasolli
Doreen Matthies
8Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20847, USA
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Hugo J. Bellen
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
4Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
9Department of Neuroscience, Baylor College of Medicine, Houston, TX 7703, USA
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  • ORCID record for Hugo J. Bellen
Maria S. Ioannou
1Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada
2Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2R3, Canada
10Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2R3, Canada
11Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada
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  • ORCID record for Maria S. Ioannou
  • For correspondence: ioannou@ualberta.ca
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Posted November 24, 2022.
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Autolysosomal exocytosis of lipids protect neurons from ferroptosis
Isha Ralhan, Jinlan Chang, Matthew J. Moulton, Lindsey D. Goodman, Nathanael Y.J. Lee, Greg Plummer, H. Amalia Pasolli, Doreen Matthies, Hugo J. Bellen, Maria S. Ioannou
bioRxiv 2022.11.24.517842; doi: https://doi.org/10.1101/2022.11.24.517842
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Autolysosomal exocytosis of lipids protect neurons from ferroptosis
Isha Ralhan, Jinlan Chang, Matthew J. Moulton, Lindsey D. Goodman, Nathanael Y.J. Lee, Greg Plummer, H. Amalia Pasolli, Doreen Matthies, Hugo J. Bellen, Maria S. Ioannou
bioRxiv 2022.11.24.517842; doi: https://doi.org/10.1101/2022.11.24.517842

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