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Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury

View ORCID ProfileJun Cao, View ORCID ProfileZexuan Hong, View ORCID ProfileFanning Zeng, View ORCID ProfileZaisheng Qin, View ORCID ProfileMiao Lin, View ORCID ProfileHao Wang, View ORCID ProfileDaming Zuo, View ORCID ProfileTao Tao
doi: https://doi.org/10.1101/2022.11.27.518054
Jun Cao
1Department of Anesthesiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China
2Department of Anesthesiology, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong 524045, China
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Zexuan Hong
1Department of Anesthesiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China
2Department of Anesthesiology, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong 524045, China
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Fanning Zeng
3Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China
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Zaisheng Qin
3Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China
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Miao Lin
4Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China
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Hao Wang
4Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China
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Daming Zuo
5Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China
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  • For correspondence: taotaomzk@smu.edu.cn zdaming@smu.edu.cn
Tao Tao
2Department of Anesthesiology, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong 524045, China
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  • For correspondence: taotaomzk@smu.edu.cn zdaming@smu.edu.cn
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Article Information

doi 
https://doi.org/10.1101/2022.11.27.518054
History 
  • November 27, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Jun Cao1,2,*,
  2. Zexuan Hong1,2,*,
  3. Fanning Zeng3,
  4. Zaisheng Qin3,
  5. Miao Lin4,
  6. Hao Wang4,
  7. Daming Zuo5,† and
  8. Tao Tao2,†
  1. 1Department of Anesthesiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China
  2. 2Department of Anesthesiology, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong 524045, China
  3. 3Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China
  4. 4Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China
  5. 5Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China
  1. ↵†Correspondence should be addressed to Tao Tao, taotaomzk{at}smu.edu.cn and Daming Zuo, zdaming{at}smu.edu.cn.
  1. ↵* Jun Cao and Zexuan Hong contributed equally

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Posted November 27, 2022.
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Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury
Jun Cao, Zexuan Hong, Fanning Zeng, Zaisheng Qin, Miao Lin, Hao Wang, Daming Zuo, Tao Tao
bioRxiv 2022.11.27.518054; doi: https://doi.org/10.1101/2022.11.27.518054
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Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury
Jun Cao, Zexuan Hong, Fanning Zeng, Zaisheng Qin, Miao Lin, Hao Wang, Daming Zuo, Tao Tao
bioRxiv 2022.11.27.518054; doi: https://doi.org/10.1101/2022.11.27.518054

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