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Tissue- and sex-specific DNA damage tracks aging in rodents and humans
View ORCID ProfileAxel Guilbaud, View ORCID ProfileFarzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsingh Balamkundu, Charles Vidoudez, Michael S. DeMott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, View ORCID ProfilePeter C. Dedon
doi: https://doi.org/10.1101/2022.11.28.518087
Axel Guilbaud
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Farzan Ghanegolmohammadi
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Yijun Wang
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Jiapeng Leng
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Alexander Kreymerman
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Jacqueline Gamboa Varela
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Jessica Garbern
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Hannah Elwell
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Fang Cao
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Elisabeth M. Ricci-Blair
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Cui Liang
3Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore
Seetharamsingh Balamkundu
3Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore
Charles Vidoudez
4Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138
Michael S. DeMott
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
Kenneth Bedi
5University of Pennsylvania Cardiovascular Institute, Philadelphia, PA, United States
Kenneth B. Margulies
5University of Pennsylvania Cardiovascular Institute, Philadelphia, PA, United States
David A. Bennett
6Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Abraham A. Palmer
7Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
8Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA
Amanda Barkley-Levenson
7Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
Richard T. Lee
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA
Peter C. Dedon
2Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
3Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore
Posted November 29, 2022.
Tissue- and sex-specific DNA damage tracks aging in rodents and humans
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsingh Balamkundu, Charles Vidoudez, Michael S. DeMott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
bioRxiv 2022.11.28.518087; doi: https://doi.org/10.1101/2022.11.28.518087
Tissue- and sex-specific DNA damage tracks aging in rodents and humans
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsingh Balamkundu, Charles Vidoudez, Michael S. DeMott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
bioRxiv 2022.11.28.518087; doi: https://doi.org/10.1101/2022.11.28.518087
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