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Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages

View ORCID ProfileMar Eroles, Javier Lopez-Alonso, Alexandre Ortega, Thomas Boudier, Khaldoun Gharzeddine, Frank Lafont, Clemens M. Franz, Arnaud Millet, Claire Valoteau, Felix Rico
doi: https://doi.org/10.1101/2022.11.29.518356
Mar Eroles
1Aix-Marseille University, INSERM, CNRS, LAI (U1067), Turing Centre for Living Systems, Marseille, France
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  • ORCID record for Mar Eroles
Javier Lopez-Alonso
2Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France
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Alexandre Ortega
1Aix-Marseille University, INSERM, CNRS, LAI (U1067), Turing Centre for Living Systems, Marseille, France
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Thomas Boudier
3Centuri, Turing Centre for Living Systems, Marseille, France
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Khaldoun Gharzeddine
4Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38700 La Tronche, France
5Department of Hepatogastroenterology, Centre Hospitalier Universitaire de Grenoble Alpes, 38700 La Tronche, France
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Frank Lafont
2Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France
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Clemens M. Franz
6WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan
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Arnaud Millet
4Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38700 La Tronche, France
5Department of Hepatogastroenterology, Centre Hospitalier Universitaire de Grenoble Alpes, 38700 La Tronche, France
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Claire Valoteau
1Aix-Marseille University, INSERM, CNRS, LAI (U1067), Turing Centre for Living Systems, Marseille, France
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Felix Rico
1Aix-Marseille University, INSERM, CNRS, LAI (U1067), Turing Centre for Living Systems, Marseille, France
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  • For correspondence: felix.rico@inserm.fr
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Article Information

doi 
https://doi.org/10.1101/2022.11.29.518356
History 
  • November 29, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Mar Eroles1,
  2. Javier Lopez-Alonso2,
  3. Alexandre Ortega1,
  4. Thomas Boudier3,
  5. Khaldoun Gharzeddine4,5,
  6. Frank Lafont2,
  7. Clemens M. Franz6,
  8. Arnaud Millet4,5,
  9. Claire Valoteau1 and
  10. Felix Rico1,*
  1. 1Aix-Marseille University, INSERM, CNRS, LAI (U1067), Turing Centre for Living Systems, Marseille, France
  2. 2Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France
  3. 3Centuri, Turing Centre for Living Systems, Marseille, France
  4. 4Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38700 La Tronche, France
  5. 5Department of Hepatogastroenterology, Centre Hospitalier Universitaire de Grenoble Alpes, 38700 La Tronche, France
  6. 6WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan
  1. ↵* Corresponding author; email: felix.rico{at}inserm.fr
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Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages
Mar Eroles, Javier Lopez-Alonso, Alexandre Ortega, Thomas Boudier, Khaldoun Gharzeddine, Frank Lafont, Clemens M. Franz, Arnaud Millet, Claire Valoteau, Felix Rico
bioRxiv 2022.11.29.518356; doi: https://doi.org/10.1101/2022.11.29.518356
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Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages
Mar Eroles, Javier Lopez-Alonso, Alexandre Ortega, Thomas Boudier, Khaldoun Gharzeddine, Frank Lafont, Clemens M. Franz, Arnaud Millet, Claire Valoteau, Felix Rico
bioRxiv 2022.11.29.518356; doi: https://doi.org/10.1101/2022.11.29.518356

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