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Proteomic profiling identifies biomarkers of COVID-19 severity

Noa C. Harriott, View ORCID ProfileAmy L. Ryan
doi: https://doi.org/10.1101/2022.11.29.518411
Noa C. Harriott
1Hastings Center for Pulmonary Research, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Southern California, Los Angeles CA 90033
2Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles CA 90033
3Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City IA 52240
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Amy L. Ryan
1Hastings Center for Pulmonary Research, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Southern California, Los Angeles CA 90033
2Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles CA 90033
3Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City IA 52240
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  • ORCID record for Amy L. Ryan
  • For correspondence: amy-l-ryan@uiowa.edu
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Abstract/Summary

SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including mesothelin (MSLN), that are expressed at significantly higher levels in severe COVID-19 subjects. In addition, we find a subset of markers associated with T-cell and dendritic cell responses to viral infection that are significantly higher in mild cases and decrease in expression as severity of COVID-19 increases, suggesting that an immediate and effective activation of T-cells is critical in modulating disease progression. Together, our findings identify new targets for further investigation as therapeutic approaches for the treatment of SARS-CoV-2 infection and prevention of complications of severe COVID-19.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://figshare.com/s/d136a74ef05c3dfa3a21

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 30, 2022.
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Proteomic profiling identifies biomarkers of COVID-19 severity
Noa C. Harriott, Amy L. Ryan
bioRxiv 2022.11.29.518411; doi: https://doi.org/10.1101/2022.11.29.518411
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Proteomic profiling identifies biomarkers of COVID-19 severity
Noa C. Harriott, Amy L. Ryan
bioRxiv 2022.11.29.518411; doi: https://doi.org/10.1101/2022.11.29.518411

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