A 2.8 Å structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

Harry Morgan; Magdalena Lipka-Lloyd; Anna J. Warren; Naomi Hughes; John Holmes; Nicolas P. Burton; Eshwar Mahenthiralingam; Ben D. Bax

doi:10.1101/2022.11.30.518515

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A 2.8 Å structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

View ORCID ProfileHarry Morgan, View ORCID ProfileMagdalena Lipka-Lloyd, Anna J. Warren, Naomi Hughes, John Holmes, Nicolas P. Burton, View ORCID ProfileEshwar Mahenthiralingam, View ORCID ProfileBen D. Bax

doi: https://doi.org/10.1101/2022.11.30.518515

Harry Morgan

1Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK

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Magdalena Lipka-Lloyd

1Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK

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Anna J. Warren

2Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK

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Naomi Hughes

3Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK

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John Holmes

4Inspiralis Limited, Norwich Research Park Innovation Centre, Norwich, NR4 7GJ

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Nicolas P. Burton

4Inspiralis Limited, Norwich Research Park Innovation Centre, Norwich, NR4 7GJ

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Eshwar Mahenthiralingam

3Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK

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Ben D. Bax

1Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK

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For correspondence: baxb@cardiff.ac.uk

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A 2.8 Å structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

Harry Morgan, Magdalena Lipka-Lloyd, Anna J. Warren, Naomi Hughes, John Holmes, Nicolas P. Burton, Eshwar Mahenthiralingam, Ben D. Bax

bioRxiv 2022.11.30.518515; doi: https://doi.org/10.1101/2022.11.30.518515

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A 2.8 Å structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

Harry Morgan, Magdalena Lipka-Lloyd, Anna J. Warren, Naomi Hughes, John Holmes, Nicolas P. Burton, Eshwar Mahenthiralingam, Ben D. Bax

bioRxiv 2022.11.30.518515; doi: https://doi.org/10.1101/2022.11.30.518515

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