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Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

Feng Fan, Xin Zhang, Zhiyu Zhang, Yuan Ding, Limei Wang, Xin Xu, Yaying Pan, Fang-Yuan Gong, Lin Jiang, Lingyu Kang, Zhihua Kou, Gan Zhao, Bin Wang, Xiao-Ming Gao
doi: https://doi.org/10.1101/2022.12.01.518127

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doi 
https://doi.org/10.1101/2022.12.01.518127
History 
  • December 2, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Feng Fan1,
  2. Xin Zhang1,
  3. Zhiyu Zhang1,
  4. Yuan Ding1,
  5. Limei Wang1,
  6. Xin Xu1,
  7. Yaying Pan2,
  8. Fang-Yuan Gong2,
  9. Lin Jiang3,
  10. Lingyu Kang3,
  11. Zhihua Kou1,
  12. Gan Zhao1,
  13. Bin Wang1,* and
  14. Xiao-Ming Gao1,*
  1. 1Advaccine Biopharmaceutics (Suzhou) Co. Ltd, Suzhou, China
  2. 2School of Biological Science and Basic Medicine, Soochow University, Suzhou, China
  3. 3Shenzhen Qinglan Biotechnology Co. Ltd., Shenzhen, China
  1. ↵*Correspondence: Xiao-Ming Gao (gaoxiaoming{at}advaccine.com) or Bin Wang (bwang{at}advaccine.com)
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Posted December 02, 2022.
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Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants
Feng Fan, Xin Zhang, Zhiyu Zhang, Yuan Ding, Limei Wang, Xin Xu, Yaying Pan, Fang-Yuan Gong, Lin Jiang, Lingyu Kang, Zhihua Kou, Gan Zhao, Bin Wang, Xiao-Ming Gao
bioRxiv 2022.12.01.518127; doi: https://doi.org/10.1101/2022.12.01.518127
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