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Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2

Aniuska Becerra-Artiles, Padma P. Nanaware, Khaja Muneeruddin, Grant C. Weaver, Scott A. Shaffer, J. Mauricio Calvo-Calle, View ORCID ProfileLawrence J. Stern
doi: https://doi.org/10.1101/2022.12.01.518643
Aniuska Becerra-Artiles
1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
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Padma P. Nanaware
1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
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Khaja Muneeruddin
2Mass Spectrometry Facility, UMass Chan Medical School, Shrewsbury MA
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Grant C. Weaver
1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
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Scott A. Shaffer
2Mass Spectrometry Facility, UMass Chan Medical School, Shrewsbury MA
3Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA
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J. Mauricio Calvo-Calle
1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
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Lawrence J. Stern
1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
3Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA
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  • ORCID record for Lawrence J. Stern
  • For correspondence: lawrence.stern@umassmed.edu
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Article Information

doi 
https://doi.org/10.1101/2022.12.01.518643
History 
  • December 1, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Aniuska Becerra-Artiles1,*,
  2. Padma P. Nanaware1,*,
  3. Khaja Muneeruddin2,
  4. Grant C. Weaver1,
  5. Scott A. Shaffer2,3,
  6. J. Mauricio Calvo-Calle1 and
  7. Lawrence J. Stern1,3,¶
  1. 1Department of Pathology, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester MA
  2. 2Mass Spectrometry Facility, UMass Chan Medical School, Shrewsbury MA
  3. 3Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA
  1. ↵¶Corresponding author. E-mail: lawrence.stern{at}umassmed.edu (LJS)
  1. ↵* These authors contributed equally to this work.

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Posted December 01, 2022.
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Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2
Aniuska Becerra-Artiles, Padma P. Nanaware, Khaja Muneeruddin, Grant C. Weaver, Scott A. Shaffer, J. Mauricio Calvo-Calle, Lawrence J. Stern
bioRxiv 2022.12.01.518643; doi: https://doi.org/10.1101/2022.12.01.518643
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Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2
Aniuska Becerra-Artiles, Padma P. Nanaware, Khaja Muneeruddin, Grant C. Weaver, Scott A. Shaffer, J. Mauricio Calvo-Calle, Lawrence J. Stern
bioRxiv 2022.12.01.518643; doi: https://doi.org/10.1101/2022.12.01.518643

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