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Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function

Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Charlotte M. de Winde, Tanya Singh, Martina Jovancheva, Robin Kettler, Janos Kriston-Vizi, View ORCID ProfileSophie E. Acton
doi: https://doi.org/10.1101/2022.12.01.518753
Spyridon Makris
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Yukti Hari-Gupta
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Jesús A. Cantoral-Rebordinos
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
2Stem Cell and Human Development Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT
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Victor G. Martinez
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
3Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain
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Harry L. Horsnell
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Charlotte M. de Winde
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
4Department for Molecular Cell Biology and Immunology, Amsterdam UMC, location VUmc, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands
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Tanya Singh
5Cell Signalling and Autophagy, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Martina Jovancheva
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Robin Kettler
5Cell Signalling and Autophagy, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Janos Kriston-Vizi
6Bioinformatic group, Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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Sophie E. Acton
1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
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  • ORCID record for Sophie E. Acton
  • For correspondence: s.acton@ucl.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2022.12.01.518753
History 
  • December 1, 2022.

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  • You are currently viewing Version 1 of this article (December 1, 2022 - 18:33).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Spyridon Makris1,
  2. Yukti Hari-Gupta1,
  3. Jesús A. Cantoral-Rebordinos1,2,*,
  4. Victor G. Martinez1,3,*,
  5. Harry L. Horsnell1,
  6. Charlotte M. de Winde1,4,*,
  7. Tanya Singh5,
  8. Martina Jovancheva1,
  9. Robin Kettler5,
  10. Janos Kriston-Vizi6 and
  11. Sophie E. Acton1,✉
  1. 1Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
  2. 2Stem Cell and Human Development Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT
  3. 3Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain
  4. 4Department for Molecular Cell Biology and Immunology, Amsterdam UMC, location VUmc, De Boelelaan 1108, 1081 HZ Amsterdam, Netherlands
  5. 5Cell Signalling and Autophagy, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
  6. 6Bioinformatic group, Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
  1. ↵✉Correspondence: s.acton{at}ucl.ac.uk
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Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Charlotte M. de Winde, Tanya Singh, Martina Jovancheva, Robin Kettler, Janos Kriston-Vizi, Sophie E. Acton
bioRxiv 2022.12.01.518753; doi: https://doi.org/10.1101/2022.12.01.518753
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Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Charlotte M. de Winde, Tanya Singh, Martina Jovancheva, Robin Kettler, Janos Kriston-Vizi, Sophie E. Acton
bioRxiv 2022.12.01.518753; doi: https://doi.org/10.1101/2022.12.01.518753

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