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Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer

Lingwei Zhu, Jinrang Kim, Kun Leng, John E. Ramos, Colin D. Kinz-Thompson, Nathan K. Karpowich, View ORCID ProfileRuben L. Gonzalez Jr., John F. Hunt
doi: https://doi.org/10.1101/2022.12.02.518933
Lingwei Zhu
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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Jinrang Kim
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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Kun Leng
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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John E. Ramos
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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Colin D. Kinz-Thompson
2Department of Chemistry, 614 Havemeyer Hall, MC3126, Columbia University, New York, NY, 10027, USA
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Nathan K. Karpowich
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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Ruben L. Gonzalez Jr.
2Department of Chemistry, 614 Havemeyer Hall, MC3126, Columbia University, New York, NY, 10027, USA
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  • ORCID record for Ruben L. Gonzalez Jr.
  • For correspondence: jfh21@columbia.edu rlg2118@columbia.edu
John F. Hunt
1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
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  • For correspondence: jfh21@columbia.edu rlg2118@columbia.edu
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Article Information

doi 
https://doi.org/10.1101/2022.12.02.518933
History 
  • December 3, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Lingwei Zhu1,
  2. Jinrang Kim1,†,
  3. Kun Leng1,†,
  4. John E. Ramos1,†,
  5. Colin D. Kinz-Thompson2,†,
  6. Nathan K. Karpowich1,†,
  7. Ruben L. Gonzalez Jr.2,§ and
  8. John F. Hunt1,§
  1. 1Department of Biological Sciences, 702A Sherman Fairchild Center, MC2434, Columbia University, New York, NY, 10027, USA
  2. 2Department of Chemistry, 614 Havemeyer Hall, MC3126, Columbia University, New York, NY, 10027, USA
  1. ↵§To whom correspondence may be addressed: JFH – jfh21{at}columbia.edu, (646)-270-5012 voice, (212)-865-8246 FAX, RLG – rlg2118{at}columbia.edu, (212)-854-1096 voice, (212)-932-1289 FAX
  • ↵† JK, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA; KL, Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA; JER, Genome LLC, Hollywood, FL 33021, USA; CDK-T, Department of Chemistry, Rutgers University-Newark, Newark, NJ, 07102, USA; NKK, Structure and Protein Sciences, Janssen Pharmaceuticals, Spring House, PA, 19477, USA.

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Posted December 03, 2022.
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Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer
Lingwei Zhu, Jinrang Kim, Kun Leng, John E. Ramos, Colin D. Kinz-Thompson, Nathan K. Karpowich, Ruben L. Gonzalez Jr., John F. Hunt
bioRxiv 2022.12.02.518933; doi: https://doi.org/10.1101/2022.12.02.518933
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Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer
Lingwei Zhu, Jinrang Kim, Kun Leng, John E. Ramos, Colin D. Kinz-Thompson, Nathan K. Karpowich, Ruben L. Gonzalez Jr., John F. Hunt
bioRxiv 2022.12.02.518933; doi: https://doi.org/10.1101/2022.12.02.518933

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