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Mega-scale experimental analysis of protein folding stability in biology and protein design
View ORCID ProfileKotaro Tsuboyama, View ORCID ProfileJustas Dauparas, Jonathan Chen, View ORCID ProfileElodie Laine, View ORCID ProfileYasser Mohseni Behbahani, Jonathan J. Weinstein, View ORCID ProfileNiall M. Mangan, View ORCID ProfileSergey Ovchinnikov, View ORCID ProfileGabriel J. Rocklin
doi: https://doi.org/10.1101/2022.12.06.519132
Kotaro Tsuboyama
1Department of Pharmacology, Northwestern University Feinberg School of Medicine; Chicago, IL, 60611 USA
2Center for Synthetic Biology, Northwestern University; Evanston, IL, 60208 USA
3PRESTO, Japan Science and Technology Agency; Chiyoda-ku, Tokyo, 102-0076, Japan
Justas Dauparas
4Department of Biochemistry, University of Washington; Seattle, WA, 98195 USA
5Institute for Protein Design, University of Washington; Seattle, WA, 98195 USA
Jonathan Chen
1Department of Pharmacology, Northwestern University Feinberg School of Medicine; Chicago, IL, 60611 USA
2Center for Synthetic Biology, Northwestern University; Evanston, IL, 60208 USA
6Master of Biotechnology Program, McCormick School of Engineering, Northwestern University; Evanston, IL, 60208 USA
Elodie Laine
9Sorbonne Université, CNRS, IBPS, Laboratory of Computational and Quantitative Biology (LCQB), UMR 7238; Paris, 75005, France
Yasser Mohseni Behbahani
9Sorbonne Université, CNRS, IBPS, Laboratory of Computational and Quantitative Biology (LCQB), UMR 7238; Paris, 75005, France
Jonathan J. Weinstein
10Department of Biomolecular Sciences, Weizmann Institute of Science; Rehovot, Israel
Niall M. Mangan
2Center for Synthetic Biology, Northwestern University; Evanston, IL, 60208 USA
7Department of Engineering Sciences and Applied Mathematics, Northwestern University; Evanston, Illinois 60208, USA
Sergey Ovchinnikov
8John Harvard Distinguished Science Fellowship Program, Harvard University; Cambridge, MA, 02138 USA
Gabriel J. Rocklin
1Department of Pharmacology, Northwestern University Feinberg School of Medicine; Chicago, IL, 60611 USA
2Center for Synthetic Biology, Northwestern University; Evanston, IL, 60208 USA
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Posted December 13, 2022.
Mega-scale experimental analysis of protein folding stability in biology and protein design
Kotaro Tsuboyama, Justas Dauparas, Jonathan Chen, Elodie Laine, Yasser Mohseni Behbahani, Jonathan J. Weinstein, Niall M. Mangan, Sergey Ovchinnikov, Gabriel J. Rocklin
bioRxiv 2022.12.06.519132; doi: https://doi.org/10.1101/2022.12.06.519132
Mega-scale experimental analysis of protein folding stability in biology and protein design
Kotaro Tsuboyama, Justas Dauparas, Jonathan Chen, Elodie Laine, Yasser Mohseni Behbahani, Jonathan J. Weinstein, Niall M. Mangan, Sergey Ovchinnikov, Gabriel J. Rocklin
bioRxiv 2022.12.06.519132; doi: https://doi.org/10.1101/2022.12.06.519132
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