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Representations of tactile object location in the retrosplenial cortex

Andreas Sigstad Lande, View ORCID ProfileKoen Vervaeke
doi: https://doi.org/10.1101/2022.12.06.519323
Andreas Sigstad Lande
1Department of Physiology; Institute of Basic Medical Sciences, University of Oslo, Norway
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Koen Vervaeke
1Department of Physiology; Institute of Basic Medical Sciences, University of Oslo, Norway
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  • ORCID record for Koen Vervaeke
  • For correspondence: koenv@medisin.uio.no
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Abstract

Little is known about how animals use tactile sensation to detect important objects and remember their location in a worldbased coordinate system. Here, we hypothesized that retrosplenial cortex (RSC), a key network for contextual memory and spatial navigation, represents the location of objects based on tactile sensation. We studied mice that palpate objects with their whiskers while running on a treadmill in a tactile virtual reality in darkness. Using two-photon Ca2+ imaging, we discovered a population of neurons in agranular RSC that signal the location of tactile objects. Tactile object location responses do not simply reflect the sensory stimulus. Instead, they are highly task- and context-dependent and often predict the upcoming object before it is within reach. In addition, most tactile object location neurons also maintain a memory trace of the object’s location. These data show that RSC encodes the location and arrangement of tactile objects in a spatial reference frame.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 06, 2022.
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Representations of tactile object location in the retrosplenial cortex
Andreas Sigstad Lande, Koen Vervaeke
bioRxiv 2022.12.06.519323; doi: https://doi.org/10.1101/2022.12.06.519323
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Representations of tactile object location in the retrosplenial cortex
Andreas Sigstad Lande, Koen Vervaeke
bioRxiv 2022.12.06.519323; doi: https://doi.org/10.1101/2022.12.06.519323

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