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Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer’s Amyloid-β Oligomer

Yuan Gao, Ramesh Prasad, Peter S. Randolph, Jens O. Watzlawik, Alicia S. Robang, Cong Guo, View ORCID ProfileScott M. Stagg, View ORCID ProfileHuan-Xiang Zhou, Terrone L. Rosenberry, View ORCID ProfileAnant K. Paravastu
doi: https://doi.org/10.1101/2022.12.06.519347
Yuan Gao
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
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Ramesh Prasad
2Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
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Peter S. Randolph
3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
4Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA
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Jens O. Watzlawik
5Departments of Neuroscience and Pharmacology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
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Alicia S. Robang
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
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Cong Guo
7Department of Physics and International Centre for Quantum and Molecular Structures, Shanghai University, 99 Shangda Road, Shanghai, China
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Scott M. Stagg
3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
4Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA
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  • ORCID record for Scott M. Stagg
Huan-Xiang Zhou
2Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
6Department of Physics, University of Illinois at Chicago, Chicago, IL 60607, USA
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  • ORCID record for Huan-Xiang Zhou
Terrone L. Rosenberry
5Departments of Neuroscience and Pharmacology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
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Anant K. Paravastu
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
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  • ORCID record for Anant K. Paravastu
  • For correspondence: anant.paravastu@chbe.gatech.edu
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Article Information

doi 
https://doi.org/10.1101/2022.12.06.519347
History 
  • December 6, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Yuan Gao1,
  2. Ramesh Prasad2,
  3. Peter S. Randolph3,4,
  4. Jens O. Watzlawik5,
  5. Alicia S. Robang1,
  6. Cong Guo7,
  7. Scott M. Stagg3,4,
  8. Huan-Xiang Zhou2,6,
  9. Terrone L. Rosenberry5 and
  10. Anant K. Paravastu1,*
  1. 1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
  2. 2Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
  3. 6Department of Physics, University of Illinois at Chicago, Chicago, IL 60607, USA
  4. 3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
  5. 4Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA
  6. 5Departments of Neuroscience and Pharmacology, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
  7. 7Department of Physics and International Centre for Quantum and Molecular Structures, Shanghai University, 99 Shangda Road, Shanghai, China
  1. ↵*Corresponding author; email: anant.paravastu{at}chbe.gatech.edu.
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Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer’s Amyloid-β Oligomer
Yuan Gao, Ramesh Prasad, Peter S. Randolph, Jens O. Watzlawik, Alicia S. Robang, Cong Guo, Scott M. Stagg, Huan-Xiang Zhou, Terrone L. Rosenberry, Anant K. Paravastu
bioRxiv 2022.12.06.519347; doi: https://doi.org/10.1101/2022.12.06.519347
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Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer’s Amyloid-β Oligomer
Yuan Gao, Ramesh Prasad, Peter S. Randolph, Jens O. Watzlawik, Alicia S. Robang, Cong Guo, Scott M. Stagg, Huan-Xiang Zhou, Terrone L. Rosenberry, Anant K. Paravastu
bioRxiv 2022.12.06.519347; doi: https://doi.org/10.1101/2022.12.06.519347

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