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SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
Brianna R. Daley, Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Dianna H. Huisman, Deepan Chatterjee, Nancy E. Sealover, Katherine Cox, James W. Askew, Zaria M. Beckley, Robert A. Svoboda, View ORCID ProfileKurt W. Fisher, Robert E. Lewis, Robert L. Kortum
doi: https://doi.org/10.1101/2022.12.06.519395
Brianna R. Daley
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
Heidi M. Vieira
3Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE
Chaitra Rao
3Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE
4Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
Jacob M. Hughes
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
Dianna H. Huisman
3Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE
Deepan Chatterjee
5Integrative Physiology and Molecular Medicine, University of Nebraska Medical Center, Omaha, NE
Nancy E. Sealover
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
Katherine Cox
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
James W. Askew
3Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE
Zaria M. Beckley
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
Robert A. Svoboda
6Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Kurt W. Fisher
6Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Robert E. Lewis
3Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE
Robert L. Kortum
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD
Posted February 19, 2023.
SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
Brianna R. Daley, Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Dianna H. Huisman, Deepan Chatterjee, Nancy E. Sealover, Katherine Cox, James W. Askew, Zaria M. Beckley, Robert A. Svoboda, Kurt W. Fisher, Robert E. Lewis, Robert L. Kortum
bioRxiv 2022.12.06.519395; doi: https://doi.org/10.1101/2022.12.06.519395
SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
Brianna R. Daley, Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Dianna H. Huisman, Deepan Chatterjee, Nancy E. Sealover, Katherine Cox, James W. Askew, Zaria M. Beckley, Robert A. Svoboda, Kurt W. Fisher, Robert E. Lewis, Robert L. Kortum
bioRxiv 2022.12.06.519395; doi: https://doi.org/10.1101/2022.12.06.519395
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