New Results
Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
View ORCID ProfileJoseph L. Watson, View ORCID ProfileDavid Juergens, View ORCID ProfileNathaniel R. Bennett, View ORCID ProfileBrian L. Trippe, View ORCID ProfileJason Yim, View ORCID ProfileHelen E. Eisenach, Woody Ahern, View ORCID ProfileAndrew J. Borst, View ORCID ProfileRobert J. Ragotte, View ORCID ProfileLukas F. Milles, View ORCID ProfileBasile I. M. Wicky, View ORCID ProfileNikita Hanikel, Samuel J. Pellock, View ORCID ProfileAlexis Courbet, William Sheffler, View ORCID ProfileJue Wang, Preetham Venkatesh, View ORCID ProfileIsaac Sappington, Susana Vázquez Torres, View ORCID ProfileAnna Lauko, View ORCID ProfileValentin De Bortoli, Emile Mathieu, Regina Barzilay, View ORCID ProfileTommi S. Jaakkola, View ORCID ProfileFrank DiMaio, View ORCID ProfileMinkyung Baek, View ORCID ProfileDavid Baker
doi: https://doi.org/10.1101/2022.12.09.519842
Joseph L. Watson
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
David Juergens
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
3Graduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA
Nathaniel R. Bennett
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
3Graduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA
Brian L. Trippe
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
4Columbia University, Department of Statistics, New York, NY 10027, USA
Jason Yim
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
6Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Helen E. Eisenach
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Woody Ahern
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
7Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98105, USA
Andrew J. Borst
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Robert J. Ragotte
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Lukas F. Milles
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Basile I. M. Wicky
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Nikita Hanikel
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Samuel J. Pellock
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Alexis Courbet
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
9Centre National de la recherche scientifique, École Normale Supérieure rue d’Ulm, Paris 75005, France
William Sheffler
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Jue Wang
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Preetham Venkatesh
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
8Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA
Isaac Sappington
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
8Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA
Susana Vázquez Torres
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
8Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA
Anna Lauko
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
8Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA
Valentin De Bortoli
9Centre National de la recherche scientifique, École Normale Supérieure rue d’Ulm, Paris 75005, France
Emile Mathieu
10Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, United Kingdom
Regina Barzilay
6Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Tommi S. Jaakkola
6Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Frank DiMaio
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
Minkyung Baek
12School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea
David Baker
1Department of Biochemistry, University of Washington, Seattle, WA 98105, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98105, USA
11Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA
Posted December 10, 2022.
Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
Joseph L. Watson, David Juergens, Nathaniel R. Bennett, Brian L. Trippe, Jason Yim, Helen E. Eisenach, Woody Ahern, Andrew J. Borst, Robert J. Ragotte, Lukas F. Milles, Basile I. M. Wicky, Nikita Hanikel, Samuel J. Pellock, Alexis Courbet, William Sheffler, Jue Wang, Preetham Venkatesh, Isaac Sappington, Susana Vázquez Torres, Anna Lauko, Valentin De Bortoli, Emile Mathieu, Regina Barzilay, Tommi S. Jaakkola, Frank DiMaio, Minkyung Baek, David Baker
bioRxiv 2022.12.09.519842; doi: https://doi.org/10.1101/2022.12.09.519842
Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
Joseph L. Watson, David Juergens, Nathaniel R. Bennett, Brian L. Trippe, Jason Yim, Helen E. Eisenach, Woody Ahern, Andrew J. Borst, Robert J. Ragotte, Lukas F. Milles, Basile I. M. Wicky, Nikita Hanikel, Samuel J. Pellock, Alexis Courbet, William Sheffler, Jue Wang, Preetham Venkatesh, Isaac Sappington, Susana Vázquez Torres, Anna Lauko, Valentin De Bortoli, Emile Mathieu, Regina Barzilay, Tommi S. Jaakkola, Frank DiMaio, Minkyung Baek, David Baker
bioRxiv 2022.12.09.519842; doi: https://doi.org/10.1101/2022.12.09.519842
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