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Proteomic discovery of chemical probes that perturb protein complexes in human cells
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
doi: https://doi.org/10.1101/2022.12.12.520090
Michael R. Lazear
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Jarrett R. Remsberg
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Martin G. Jaeger
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Katherine Rothamel
3Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA
Hsuan-lin Her
3Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA
Kristen E. DeMeester
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Evert Njomen
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Simon J. Hogg
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Jahan Rahman
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Landon R. Whitby
5Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA
Sang Joon Won
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Michael A. Schafroth
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Daisuke Ogasawara
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Minoru Yokoyama
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Garrett L. Lindsey
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Haoxin Li
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Jason Germain
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Sabrina Barbas
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Joan Vaughan
6Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA
Thomas W. Hanigan
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Vincent F. Vartabedian
7Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA
Christopher J. Reinhardt
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Melissa M. Dix
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Seong Joo Koo
8Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
Inha Heo
8Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
John R. Teijaro
7Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA
Gabriel M. Simon
5Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA
Brahma Ghosh
9Discovery Chemistry, Janssen Research & Development, Spring House, PA 19477, USA
Omar Abdel-Wahab
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Kay Ahn
10Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Spring House, Pennsylvania 19477, USA
Alan Saghatelian
6Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA
Bruno Melillo
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
11Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
Stuart L. Schreiber
11Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA
12Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Gene W. Yeo
3Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA
Benjamin F. Cravatt
2Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA
Article usage
Posted December 13, 2022.
Proteomic discovery of chemical probes that perturb protein complexes in human cells
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
bioRxiv 2022.12.12.520090; doi: https://doi.org/10.1101/2022.12.12.520090
Proteomic discovery of chemical probes that perturb protein complexes in human cells
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
bioRxiv 2022.12.12.520090; doi: https://doi.org/10.1101/2022.12.12.520090
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