Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Can Yue; Weiliang Song; Lei Wang; Fanchong Jian; Xiaosu Chen; Fei Gao; Zhongyang Shen; Youchun Wang; Xiangxi Wang; Yunlong Cao

doi:10.1101/2023.01.03.522427

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Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

doi: https://doi.org/10.1101/2023.01.03.522427

Can Yue

1CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China

2Changping Laboratory, Beijing, P.R. China

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Weiliang Song

2Changping Laboratory, Beijing, P.R. China

3Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P.R. China

4School of Life Sciences, Peking University, Beijing, P.R. China

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Lei Wang

1CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China

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Fanchong Jian

1CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China

2Changping Laboratory, Beijing, P.R. China

5College of Chemistry and Molecular Engineering, Peking University, Beijing, P.R. China

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Xiaosu Chen

6Frontier Research Center for Cell Response, Institute of Immunology, College of Life Sciences, Nankai University, Tianjin 300071, China

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Fei Gao

7Department of Pulmonary and Critical Care Medicine, The Fourth Hospital of Inner Mongolia, Hohhot 010058, China

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Zhongyang Shen

8Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China

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Youchun Wang

2Changping Laboratory, Beijing, P.R. China

9Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, P.R. China

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Xiangxi Wang

1CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China

2Changping Laboratory, Beijing, P.R. China

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For correspondence: xiangxi@ibp.ac.cn yunlongcao@pku.edu.cn

Yunlong Cao

2Changping Laboratory, Beijing, P.R. China

3Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, P.R. China

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For correspondence: xiangxi@ibp.ac.cn yunlongcao@pku.edu.cn

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Posted January 05, 2023.

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Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

bioRxiv 2023.01.03.522427; doi: https://doi.org/10.1101/2023.01.03.522427

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Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

bioRxiv 2023.01.03.522427; doi: https://doi.org/10.1101/2023.01.03.522427

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