Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

Jasmin Rees; Gaurab Sarangi; Qing Cheng; Martin Floor; Aida M Andrés; Baldomero Oliva Miguel; Jordi Villà-Freixa; Elias SJ Arnér; Sergi Castellano

doi:10.1101/2023.01.03.522577

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Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

View ORCID ProfileJasmin Rees, Gaurab Sarangi, Qing Cheng, Martin Floor, Aida M Andrés, Baldomero Oliva Miguel, Jordi Villà-Freixa, View ORCID ProfileElias SJ Arnér, View ORCID ProfileSergi Castellano

doi: https://doi.org/10.1101/2023.01.03.522577

Jasmin Rees

1Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

2Division of Biosciences, University College London, London, United Kingdom

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ORCID record for Jasmin Rees

Gaurab Sarangi

3Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

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Qing Cheng

4Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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Martin Floor

5Department of Biosciences, Faculty of Sciences and Technology, Universitat de Vic - Universitat Central de Catalunya, Vic, Spain

6Barcelona Supercomputing Center (BSC), Barcelona, Spain

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Aida M Andrés

2Division of Biosciences, University College London, London, United Kingdom

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Baldomero Oliva Miguel

7Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain

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Jordi Villà-Freixa

5Department of Biosciences, Faculty of Sciences and Technology, Universitat de Vic - Universitat Central de Catalunya, Vic, Spain

8Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central (IRIS-CC), Vic, Spain

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Elias SJ Arnér

4Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

9Department of Selenoprotein Research, National Institute of Oncology, Budapest, Hungary

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Sergi Castellano

1Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

10UCL Genomics, University College London, London, United Kingdom

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For correspondence: s.castellano@ucl.ac.uk

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Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

Jasmin Rees, Gaurab Sarangi, Qing Cheng, Martin Floor, Aida M Andrés, Baldomero Oliva Miguel, Jordi Villà-Freixa, Elias SJ Arnér, Sergi Castellano

bioRxiv 2023.01.03.522577; doi: https://doi.org/10.1101/2023.01.03.522577

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Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

Jasmin Rees, Gaurab Sarangi, Qing Cheng, Martin Floor, Aida M Andrés, Baldomero Oliva Miguel, Jordi Villà-Freixa, Elias SJ Arnér, Sergi Castellano

bioRxiv 2023.01.03.522577; doi: https://doi.org/10.1101/2023.01.03.522577

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