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Maternal diesel exposure and maternal choline supplementation interactions in fetal and placental immune factors

View ORCID ProfileSara V Maurer, Jessica L Bolton, Staci D Bilbo, Christina L Williams
doi: https://doi.org/10.1101/2023.01.04.522511
Sara V Maurer
1University of Iowa
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  • For correspondence: sara-maurer@uiowa.edu
Jessica L Bolton
2Georgia State University
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Staci D Bilbo
3Duke University
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Christina L Williams
3Duke University
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Abstract

Air pollution causes widespread inflammatory changes in the body and brain. When exposure to air pollution occurs early in development, children exhibit impaired working memory ability (Sunyer et al., 2015). In addition, prenatal exposure to diesel particulate matter (DEP) increases inflammatory cytokine expression in the whole brain of embryonic day 18 (E18) males and leads to adverse long-term negative outcomes (Bolton et al., 2012). In contrast, dietary choline supplementation is negatively correlated with inflammatory cytokine production in adult rats and cultured human cells (Zhang et al., 2018; Jiang et al., 2014). When administered as a supplement to pregnant rats, choline also improves working memory in adulthood (Meck et al., 2008; Meck & Williams, 1999; 1997). The current study sought to determine if prenatal dietary choline supplementation protects against the effects of air pollution in the developing brain and in the placenta and fetal liver. These data revealed region-specific microglial morphology alterations in fetal brain and in inflammatory gene expression in the placenta and fetal liver (specifically, Tnf, Tlr2, Tlr4, and Itgam) due to maternal choline supplementation and/or maternal air pollution exposure. We found that DEP led to changes in microglial morphology in the fetal dentate gyrus of E18 male, but not female, fetuses. In the placenta and fetal liver of males, inflammatory gene expression was affected by both DEP and maternal choline supplementation. However, maternal choline supplementation alone upregulated inflammatory gene expression in females, which may indicate an alteration in maturation rate. These data further contribute to the growing literature indicating region- and tissue-specificity in the developmental immune system in the context of maternal exposures.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://data.mendeley.com/datasets/dn2cnhcnnm

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 05, 2023.
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Maternal diesel exposure and maternal choline supplementation interactions in fetal and placental immune factors
Sara V Maurer, Jessica L Bolton, Staci D Bilbo, Christina L Williams
bioRxiv 2023.01.04.522511; doi: https://doi.org/10.1101/2023.01.04.522511
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Maternal diesel exposure and maternal choline supplementation interactions in fetal and placental immune factors
Sara V Maurer, Jessica L Bolton, Staci D Bilbo, Christina L Williams
bioRxiv 2023.01.04.522511; doi: https://doi.org/10.1101/2023.01.04.522511

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