New Results
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
Mikhail Kolmogorov, Kimberley J. Billingsley, Mira Mastoras, Melissa Meredith, Jean Monlong, Ryan Lorig-Roach, Mobin Asri, Pilar Alvarez Jerez, Laksh Malik, Ramita Dewan, Xylena Reed, Rylee M. Genner, Kensuke Daida, Sairam Behera, Kishwar Shafin, Trevor Pesout, Jeshuwin Prabakaran, Paolo Carnevali, North American Brain Expression Consortium (NABEC), View ORCID ProfileJianzhi Yang, View ORCID ProfileArang Rhie, Sonja W. Scholz, Bryan J. Traynor, Karen H. Miga, Miten Jain, View ORCID ProfileWinston Timp, Adam M. Phillippy, Mark Chaisson, Fritz J. Sedlazeck, Cornelis Blauwendraat, Benedict Paten
doi: https://doi.org/10.1101/2023.01.12.523790
Mikhail Kolmogorov
1Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA
Kimberley J. Billingsley
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Mira Mastoras
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Melissa Meredith
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Jean Monlong
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Ryan Lorig-Roach
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Mobin Asri
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Pilar Alvarez Jerez
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Laksh Malik
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Ramita Dewan
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Xylena Reed
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Rylee M. Genner
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Kensuke Daida
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Sairam Behera
5Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
Kishwar Shafin
6Google LLC, 1600 Amphitheatre Pkwy, Mountain View, CA, USA
Trevor Pesout
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Jeshuwin Prabakaran
1Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA
14Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA
Paolo Carnevali
7Chan Zuckerberg Initiative, Redwood City, CA, USA
Jianzhi Yang
8Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, USA
Arang Rhie
9Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Sonja W. Scholz
10Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
11Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA
Bryan J. Traynor
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Karen H. Miga
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Miten Jain
12Department of Bioengineering, Department of Physics, Northeastern University, Boston, MA, USA
Winston Timp
13Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
Adam M. Phillippy
9Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Mark Chaisson
8Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, USA
Fritz J. Sedlazeck
5Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
15Department of Computer Science, Rice University, Houston, Texas, USA
Cornelis Blauwendraat
2Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Benedict Paten
4UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
Posted April 05, 2023.
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
Mikhail Kolmogorov, Kimberley J. Billingsley, Mira Mastoras, Melissa Meredith, Jean Monlong, Ryan Lorig-Roach, Mobin Asri, Pilar Alvarez Jerez, Laksh Malik, Ramita Dewan, Xylena Reed, Rylee M. Genner, Kensuke Daida, Sairam Behera, Kishwar Shafin, Trevor Pesout, Jeshuwin Prabakaran, Paolo Carnevali, North American Brain Expression Consortium (NABEC), Jianzhi Yang, Arang Rhie, Sonja W. Scholz, Bryan J. Traynor, Karen H. Miga, Miten Jain, Winston Timp, Adam M. Phillippy, Mark Chaisson, Fritz J. Sedlazeck, Cornelis Blauwendraat, Benedict Paten
bioRxiv 2023.01.12.523790; doi: https://doi.org/10.1101/2023.01.12.523790
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
Mikhail Kolmogorov, Kimberley J. Billingsley, Mira Mastoras, Melissa Meredith, Jean Monlong, Ryan Lorig-Roach, Mobin Asri, Pilar Alvarez Jerez, Laksh Malik, Ramita Dewan, Xylena Reed, Rylee M. Genner, Kensuke Daida, Sairam Behera, Kishwar Shafin, Trevor Pesout, Jeshuwin Prabakaran, Paolo Carnevali, North American Brain Expression Consortium (NABEC), Jianzhi Yang, Arang Rhie, Sonja W. Scholz, Bryan J. Traynor, Karen H. Miga, Miten Jain, Winston Timp, Adam M. Phillippy, Mark Chaisson, Fritz J. Sedlazeck, Cornelis Blauwendraat, Benedict Paten
bioRxiv 2023.01.12.523790; doi: https://doi.org/10.1101/2023.01.12.523790
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