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A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies
View ORCID ProfileCarmen Martin-Alonso, View ORCID ProfileShervin Tabrizi, View ORCID ProfileKan Xiong, Timothy Blewett, Sahil Patel, Zhenyi An, Sainetra Sridhar, Ahmet Bekdemir, Douglas Shea, Ava P. Amini, Shih-Ting Wang, Jesse Kirkpatrick, Justin Rhoades, Todd R. Golub, View ORCID ProfileJ. Christopher Love, Viktor A. Adalsteinsson, Sangeeta N. Bhatia
doi: https://doi.org/10.1101/2023.01.13.524003
Carmen Martin-Alonso
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
2Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA
Shervin Tabrizi
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
4Department of Radiation Oncology, Massachusetts General Hospital; Boston, MA, USA
5Harvard Medical School; Boston, MA, USA
Kan Xiong
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Timothy Blewett
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Sahil Patel
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
6Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital; Boston, MA, USA
Zhenyi An
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Sainetra Sridhar
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Ahmet Bekdemir
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
Douglas Shea
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Ava P. Amini
7Microsoft Research New England; Cambridge, MA, USA
Shih-Ting Wang
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
Jesse Kirkpatrick
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
2Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA
Justin Rhoades
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Todd R. Golub
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
5Harvard Medical School; Boston, MA, USA
J. Christopher Love
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
8Department of Chemical Engineering, Massachusetts Institute of Technology; Cambridge, MA, USA
Viktor A. Adalsteinsson
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Sangeeta N. Bhatia
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA
2Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
9Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology; Cambridge, MA, USA
10Department of Medicine, Brigham and Women’s Hospital; Boston, MA, USA
11Wyss Institute at Harvard University; Boston, USA
12Howard Hughes Medical Institute; Cambridge, MA, USA
Article usage
Posted January 14, 2023.
A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies
Carmen Martin-Alonso, Shervin Tabrizi, Kan Xiong, Timothy Blewett, Sahil Patel, Zhenyi An, Sainetra Sridhar, Ahmet Bekdemir, Douglas Shea, Ava P. Amini, Shih-Ting Wang, Jesse Kirkpatrick, Justin Rhoades, Todd R. Golub, J. Christopher Love, Viktor A. Adalsteinsson, Sangeeta N. Bhatia
bioRxiv 2023.01.13.524003; doi: https://doi.org/10.1101/2023.01.13.524003
A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies
Carmen Martin-Alonso, Shervin Tabrizi, Kan Xiong, Timothy Blewett, Sahil Patel, Zhenyi An, Sainetra Sridhar, Ahmet Bekdemir, Douglas Shea, Ava P. Amini, Shih-Ting Wang, Jesse Kirkpatrick, Justin Rhoades, Todd R. Golub, J. Christopher Love, Viktor A. Adalsteinsson, Sangeeta N. Bhatia
bioRxiv 2023.01.13.524003; doi: https://doi.org/10.1101/2023.01.13.524003
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