Histone acetylation insulator SET orchestrates PP2A inhibition and super-enhancer activation

He Xu; Di Wu; Jin Xu; Yubin Lei; Yalan Lei; Xianjun Yu; Si Shi

doi:10.1101/2023.01.15.524091

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Histone acetylation insulator SET orchestrates PP2A inhibition and super-enhancer activation

He Xu, Di Wu, Jin Xu, Yubin Lei, Yalan Lei, Xianjun Yu, Si Shi

doi: https://doi.org/10.1101/2023.01.15.524091

He Xu

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

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Di Wu

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

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For correspondence: wudi@fudanpci.org diwu09@fudan.edu.cn yuxianjun@fudanpci.org shisi@fudanpci.org

Jin Xu

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

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Yubin Lei

5Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, China. 310024;

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Yalan Lei

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

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Xianjun Yu

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

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For correspondence: wudi@fudanpci.org diwu09@fudan.edu.cn yuxianjun@fudanpci.org shisi@fudanpci.org

Si Shi

1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;

3Shanghai Pancreatic Cancer Institute, Shanghai 200032, China;

4Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China;

6Lead Contact

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For correspondence: wudi@fudanpci.org diwu09@fudan.edu.cn yuxianjun@fudanpci.org shisi@fudanpci.org