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A Unified Physiological Process Links Global Patterns of Functional MRI, Respiratory Activity, and Autonomic Signaling

Taylor Bolt, Shiyu Wang, Jason S. Nomi, Roni Setton, Benjamin P. Gold, Blaise deB.Frederick, View ORCID ProfileR Nathan Spreng, Shella D. Keilholz, Lucina Q. Uddin, Catie Chang
doi: https://doi.org/10.1101/2023.01.19.524818
Taylor Bolt
1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
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  • For correspondence: taylor.s.bolt@gmail.com
Shiyu Wang
2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
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Jason S. Nomi
1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
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Roni Setton
5Department of Psychology, Harvard University, Boston, MA, USA
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Benjamin P. Gold
3Departments of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA
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Blaise deB.Frederick
6Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts
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R Nathan Spreng
7Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University,Montreal, QC, Canada
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  • ORCID record for R Nathan Spreng
Shella D. Keilholz
8Emory University/Georgia Institute of Technology, Atlanta, GA, USA
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Lucina Q. Uddin
1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
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Catie Chang
2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
3Departments of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA
4Department of Computer Science, Vanderbilt University, Nashville, TN, USA
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Abstract

Global signal fluctuations are a dominant source of variance in spontaneous BOLD activity. These brain-wide signals co-occur with respiratory and other physiological changes. An often-overlooked possibility is that these physiological associations with global BOLD fluctuations are components of a unified physiological process. Here we combine analysis of multi-modal physiological recordings with simultaneous EEG-fMRI data to demonstrate that global BOLD fluctuations are embedded in a physiological network spanning neural, cardiovascular, pulmonary, exocrine (sweat glands) and smooth muscle (pupil dilator) systems. We further show that these co-fluctuations can be initiated by voluntary changes in respiratory rate and depth. We propose that respiratory variability and its concomitant physiological dynamics are essential explanatory ingredients in the origin of global BOLD fluctuations.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 20, 2023.
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A Unified Physiological Process Links Global Patterns of Functional MRI, Respiratory Activity, and Autonomic Signaling
Taylor Bolt, Shiyu Wang, Jason S. Nomi, Roni Setton, Benjamin P. Gold, Blaise deB.Frederick, R Nathan Spreng, Shella D. Keilholz, Lucina Q. Uddin, Catie Chang
bioRxiv 2023.01.19.524818; doi: https://doi.org/10.1101/2023.01.19.524818
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A Unified Physiological Process Links Global Patterns of Functional MRI, Respiratory Activity, and Autonomic Signaling
Taylor Bolt, Shiyu Wang, Jason S. Nomi, Roni Setton, Benjamin P. Gold, Blaise deB.Frederick, R Nathan Spreng, Shella D. Keilholz, Lucina Q. Uddin, Catie Chang
bioRxiv 2023.01.19.524818; doi: https://doi.org/10.1101/2023.01.19.524818

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