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A Novel Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-neutralizing SARS-CoV-2 Activity Including BQ.1.1 Variant

Leire de Campos-Mata, Benjamin Trinité, Andrea Modrego, Sonia Tejedor Vaquero, Edwards Pradenas, Natalia Rodrigo Melero, Diego Carlero, Silvia Marfil, Anna Pons-Grífols, María Teresa Bueno-Carrasco, César Santiago, Ferran Tarrés-Freixas, Victor Urrea, Nuria Izquierdo, Eva Riveira-Muñoz, Ester Ballana, Mónica Pérez, Júlia Vergara-Alert, Joaquim Segalés, Carlo Carolis, Rocío Arranz, Julià Blanco, Giuliana Magri
doi: https://doi.org/10.1101/2023.01.20.524748

Article Information

doi 
https://doi.org/10.1101/2023.01.20.524748
History 
  • January 23, 2023.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Leire de Campos-Mata1,#,
  2. Benjamin Trinité2,#,
  3. Andrea Modrego3,#,
  4. Sonia Tejedor Vaquero1,
  5. Edwards Pradenas2,
  6. Natalia Rodrigo Melero4,
  7. Diego Carlero3,
  8. Silvia Marfil2,
  9. Anna Pons-Grífols2,
  10. María Teresa Bueno-Carrasco3,
  11. César Santiago3,
  12. Ferran Tarrés-Freixas2,
  13. Victor Urrea2,
  14. Nuria Izquierdo2,5,
  15. Eva Riveira-Muñoz2,
  16. Ester Ballana2,5,6,
  17. Mónica Pérez7,
  18. Júlia Vergara-Alert7,8,
  19. Joaquim Segalés8,9,
  20. Carlo Carolis4,§,*,
  21. Rocío Arranz3,§,*,
  22. Julià Blanco2,5,6,10,§,* and
  23. Giuliana Magri1,11,§,*
  1. 1Translational Clinical Research Program, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
  2. 2IrsiCaixa AIDS Research Institute, Hospital Germans Trias I Pujol, Campus Can Ruti, Badalona, Spain
  3. 3Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
  4. 4Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
  5. 5CIBERINFEC, ISCIII, Madrid, Spain
  6. 6Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Badalona, Spain
  7. 7Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain
  8. 8IRTA. Programa de Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain
  9. 9Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain
  10. 10Infectious Diseases and Immunity, Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Barcelona, Spain
  11. 11Immunology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
  1. ↵*Correspondence: Carlo Carolis, carlo.carolis{at}crg.eu; Julià Blanco, jblanco{at}irsicaixa.es; Rocío Arranz, rarranz{at}cnb.csic.es and Giuliana Magri, gmagri{at}imim.es

  1. ↵# These authors contributed equally

  2. ↵§ These authors contributed equally

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Posted January 23, 2023.
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A Novel Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-neutralizing SARS-CoV-2 Activity Including BQ.1.1 Variant
Leire de Campos-Mata, Benjamin Trinité, Andrea Modrego, Sonia Tejedor Vaquero, Edwards Pradenas, Natalia Rodrigo Melero, Diego Carlero, Silvia Marfil, Anna Pons-Grífols, María Teresa Bueno-Carrasco, César Santiago, Ferran Tarrés-Freixas, Victor Urrea, Nuria Izquierdo, Eva Riveira-Muñoz, Ester Ballana, Mónica Pérez, Júlia Vergara-Alert, Joaquim Segalés, Carlo Carolis, Rocío Arranz, Julià Blanco, Giuliana Magri
bioRxiv 2023.01.20.524748; doi: https://doi.org/10.1101/2023.01.20.524748
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