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Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion
View ORCID ProfileStijn De Munter, View ORCID ProfileJuliane Buhl, View ORCID ProfileLaurenz De Cock, View ORCID ProfileAlexander Van Parys, View ORCID ProfileWillem Daneels, View ORCID ProfileEva Pascal, Lucas Deseins, View ORCID ProfileJoline Ingels, Glenn Goetgeluk, View ORCID ProfileLore Billiet, View ORCID ProfileMelissa Pille, View ORCID ProfileNiels Vandamme, View ORCID ProfileJo Van Dorpe, View ORCID ProfileFritz Offner, Erik Depla, Jan Tavernier, View ORCID ProfileTessa Kerre, View ORCID ProfileJarno Drost, View ORCID ProfileBart Vandekerckhove
doi: https://doi.org/10.1101/2023.01.22.523482
Stijn De Munter
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Juliane Buhl
3Princess Máxima Center and Oncode Institute, Utrecht, The Netherlands
Laurenz De Cock
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
4Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
Alexander Van Parys
5Orionis Biosciences BV, Ghent, Belgium
Willem Daneels
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
6Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
7Department of Hematology, Ghent University Hospital, Ghent, Belgium
Eva Pascal
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Lucas Deseins
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Joline Ingels
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Glenn Goetgeluk
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Lore Billiet
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Melissa Pille
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Niels Vandamme
8VIB Single Cell Core, Ghent, Belgium
Jo Van Dorpe
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
9Department of Pathology, Ghent University Hospital, Ghent, Belgium
Fritz Offner
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
6Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
7Department of Hematology, Ghent University Hospital, Ghent, Belgium
Erik Depla
5Orionis Biosciences BV, Ghent, Belgium
Jan Tavernier
5Orionis Biosciences BV, Ghent, Belgium
Tessa Kerre
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
6Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
7Department of Hematology, Ghent University Hospital, Ghent, Belgium
Jarno Drost
3Princess Máxima Center and Oncode Institute, Utrecht, The Netherlands
Bart Vandekerckhove
1Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
2Cancer Research Institute Ghent (CRIG), Ghent, Belgium
10GMP Unit Cell Therapy, Ghent University Hospital, Ghent, Belgium
Article usage
Posted January 22, 2023.
Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion
Stijn De Munter, Juliane Buhl, Laurenz De Cock, Alexander Van Parys, Willem Daneels, Eva Pascal, Lucas Deseins, Joline Ingels, Glenn Goetgeluk, Lore Billiet, Melissa Pille, Niels Vandamme, Jo Van Dorpe, Fritz Offner, Erik Depla, Jan Tavernier, Tessa Kerre, Jarno Drost, Bart Vandekerckhove
bioRxiv 2023.01.22.523482; doi: https://doi.org/10.1101/2023.01.22.523482
Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion
Stijn De Munter, Juliane Buhl, Laurenz De Cock, Alexander Van Parys, Willem Daneels, Eva Pascal, Lucas Deseins, Joline Ingels, Glenn Goetgeluk, Lore Billiet, Melissa Pille, Niels Vandamme, Jo Van Dorpe, Fritz Offner, Erik Depla, Jan Tavernier, Tessa Kerre, Jarno Drost, Bart Vandekerckhove
bioRxiv 2023.01.22.523482; doi: https://doi.org/10.1101/2023.01.22.523482
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