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Dynamics of Changes in Cadmium Levels in Environmental Objects and its Impact on the Bio-Elemental Composition of Living Organisms

View ORCID ProfileLarysa Nechytailo, View ORCID ProfileSvitlana Danyliv, View ORCID ProfileLiliia Kuras, View ORCID ProfileSvitlana Shkurashivska, Aleksandra Buchko
doi: https://doi.org/10.1101/2023.01.22.525090
Larysa Nechytailo
1Department of Biological and Medical Chemistry, Ivano Frankivsk National Medical University,
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  • For correspondence: ufg.ccm0401@gmail.com larysa.nechytailo@gmail.com
Svitlana Danyliv
2Department of Pharmaceutical Management, Drug Technology and Pharmacognosy, Ivano-Frankivsk national medical university,
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Liliia Kuras
3Department of Biological and Medical Chemistry named after G.O. Babenko, Ivano-Frankivsk National Medical University,
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  • For correspondence: kuras1205@ukr.net
Svitlana Shkurashivska
4Department of Biological and Medical Chemistry named after G.O. Babenko, Ivano-Frankivsk National Medical University,
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Aleksandra Buchko
5Department of Pharmaceutical Management, Drug Technology and Pharmacognosy, Ivano-Fankivsk National Medical University,
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  • For correspondence: l_bucko@ukr.net
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Abstract

As a result of intensive anthropogenic impact in the biosphere there is a rapid process of accumulation of heavy metal salts. They have led to the aggravation of problems associated with the pollution of ecosystems and basic food products of plant and animal origin. Environmental pollution by these compounds is caused by their persistence in environmental objects, migration ability, accumulation by plants. This contributes to their accumulation in the human environment. A number of studies have shown that heavy metals have mutagenic, toxic effects and affect the intensity of biochemical processes. Therefore, the presence of heavy metals in the environment is extremely undesirable. Moreover, the ecological state of the environment is directly related to changes in the human internal environment. Deficiency or excess of certain bioelements in soils and drinking water or non-compliance with its stable chemical composition causes the development of dysmicroelementosis. The ecological situation of the Carpathian region is closely related to the state of soils and water resources. In this regard, it is advisable to study and control the level of cadmium compounds in the environment of the region. The study of the effect of cadmium intoxication on the macro- and microelement composition of the brain and myocardium of experimental animals is also worthwhile.

Materials and methods Soils and drinking water of the plain, foothill and mountainous zones of the region, as well as organs and tissues of experimental animals served as the object of research. Cadmium levels in drinking water and myocardial tissues and brain of experimental animals have been measured by atomic absorption spectroscopy.

Results and discussion The study of soils in the Prykarpattia region has revealed an increase in the toxic element cadmium. Its content is 1.1-1.5 times higher than background levels. The analysis of drinking water allowed to establish that a significant number of people living in the plain and foothill zone of the region consume water with a high content of cadmium. The main stages of cadmium intake and accumulation in plants have been analyzed.

Significant disorders in the body of experimental animals under conditions of excessive intake of cadmium compounds have been revealed. It was accompanied by the accumulation of cadmium in the myocardium and brain, on the background of redistribution of vital macronutrients calcium and magnesium along with micronutrients copper and zinc. Thus, excessive intake of cadmium salts causes the development of dysmicroelementosis, which is accompanied by a violation of the homeostasis of a living organism. It is suggested to conduct continuous monitoring of the level of toxicants in the ecosystem as an integral component of environmental monitoring.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 23, 2023.
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Dynamics of Changes in Cadmium Levels in Environmental Objects and its Impact on the Bio-Elemental Composition of Living Organisms
Larysa Nechytailo, Svitlana Danyliv, Liliia Kuras, Svitlana Shkurashivska, Aleksandra Buchko
bioRxiv 2023.01.22.525090; doi: https://doi.org/10.1101/2023.01.22.525090
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Dynamics of Changes in Cadmium Levels in Environmental Objects and its Impact on the Bio-Elemental Composition of Living Organisms
Larysa Nechytailo, Svitlana Danyliv, Liliia Kuras, Svitlana Shkurashivska, Aleksandra Buchko
bioRxiv 2023.01.22.525090; doi: https://doi.org/10.1101/2023.01.22.525090

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