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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

View ORCID ProfileRachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, View ORCID ProfileP. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes
doi: https://doi.org/10.1101/2023.01.23.525131
Rachel M. Kratofil
1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada
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  • ORCID record for Rachel M. Kratofil
Trevor E. Randall
3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
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Josefien W. Hommes
1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada
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Rehnuma Sejuty
3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
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Jessica Chisholm
3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
4Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada
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Deepa Raju
5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
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Mario Vargas
5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
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P. Lynne Howell
5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
6Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
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  • ORCID record for P. Lynne Howell
Gerald B. Pier
7Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, United States
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Douglas W. Morck
3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
4Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada
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Joe J. Harrison
3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
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Paul Kubes
1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada
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  • For correspondence: pkubes@ucalgary.ca
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Article Information

doi 
https://doi.org/10.1101/2023.01.23.525131
History 
  • January 23, 2023.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Rachel M. Kratofil1,2,
  2. Trevor E. Randall3,
  3. Josefien W. Hommes1,2,
  4. Rehnuma Sejuty3,
  5. Jessica Chisholm3,4,
  6. Deepa Raju5,
  7. Mario Vargas5,
  8. P. Lynne Howell5,6,
  9. Gerald B. Pier7,
  10. Douglas W. Morck3,4,
  11. Joe J. Harrison3 and
  12. Paul Kubes1,2,*
  1. 1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
  2. 2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada
  3. 3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
  4. 4Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada
  5. 5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
  6. 6Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
  7. 7Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, United States
  1. ↵*Corresponding author, Email
    : pkubes{at}ucalgary.ca
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Posted January 23, 2023.
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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections
Rachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, P. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes
bioRxiv 2023.01.23.525131; doi: https://doi.org/10.1101/2023.01.23.525131
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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections
Rachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, P. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes
bioRxiv 2023.01.23.525131; doi: https://doi.org/10.1101/2023.01.23.525131

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