PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

Rachel M. Kratofil; Trevor E. Randall; Josefien W. Hommes; Rehnuma Sejuty; Jessica Chisholm; Deepa Raju; Mario Vargas; P. Lynne Howell; Gerald B. Pier; Douglas W. Morck; Joe J. Harrison; Paul Kubes

doi:10.1101/2023.01.23.525131

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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

View ORCID ProfileRachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, View ORCID ProfileP. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes

doi: https://doi.org/10.1101/2023.01.23.525131

Rachel M. Kratofil

1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada

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ORCID record for Rachel M. Kratofil

Trevor E. Randall

3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Josefien W. Hommes

1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada

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Rehnuma Sejuty

3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Jessica Chisholm

3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

4Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada

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Deepa Raju

5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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Mario Vargas

5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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P. Lynne Howell

5Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

6Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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ORCID record for P. Lynne Howell

Gerald B. Pier

7Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, United States

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Douglas W. Morck

3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

4Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada

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Joe J. Harrison

3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Paul Kubes

1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

2Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada

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For correspondence: pkubes@ucalgary.ca

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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

Rachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, P. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes

bioRxiv 2023.01.23.525131; doi: https://doi.org/10.1101/2023.01.23.525131

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PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

Rachel M. Kratofil, Trevor E. Randall, Josefien W. Hommes, Rehnuma Sejuty, Jessica Chisholm, Deepa Raju, Mario Vargas, P. Lynne Howell, Gerald B. Pier, Douglas W. Morck, Joe J. Harrison, Paul Kubes

bioRxiv 2023.01.23.525131; doi: https://doi.org/10.1101/2023.01.23.525131

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