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History
- January 23, 2023.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Elien De Bousser1,2,4,*,°,
- Nele Festjens1,2,4,*,
- Leander Meuris1,2,4,
- Evelyn Plets1,2,
- Annelies Van Hecke1,2,
- Elise Wyseure1,2,
- Stijn De Munter3,4,
- Bart Vandekerckhove3,4 and
- Nico Callewaert1,2,4,°
- 1VIB-UGent Center for Medical Biotechnology
- 2Department for Biochemistry and Microbiology, Ghent University, Technologiepark-Zwijnaarde 75, B-9052 Gent, Belgium
- 3Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium
- 4Cancer Research Institute Ghent (CRIG), Ghent, Belgium
- ↵°Correspondence should be addressed to NC (Nico.Callewaert{at}vib-ugent.be) and EDB (Elien.DeBousser{at}vib-ugent.be)
↵* These authors contributed equally to this work
Author contributions EDB and NF were responsible for the experimental design and data analysis. EDB, NF, EP, AVH and EW acquired the data. LM performed the statistical analyses. SDM designed the CD70 nanoCAR and set up the assays for functional analysis under the supervision of BV. NC initiated and supervised the project and manuscript writing.