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Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations
View ORCID ProfileDouglas Yao, Loic Binan, Jon Bezney, Brooke Simonton, Jahanara Freedman, Chris J. Frangieh, Kushal Dey, Kathryn Geiger-Schuller, Basak Eraslan, Alexander Gusev, Aviv Regev, Brian Cleary
doi: https://doi.org/10.1101/2023.01.23.525200
Douglas Yao
1Program in Systems, Synthetic, and Quantitative Biology, Harvard University, Cambridge, MA
Loic Binan
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
Jon Bezney
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
13Department of Genetics, Stanford University School of Medicine, Stanford, CA
Brooke Simonton
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
Jahanara Freedman
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
Chris J. Frangieh
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA
Kushal Dey
4Harvard T.H. Chan School of Public Health, Boston, MA
Kathryn Geiger-Schuller
5Genentech, South San Francisco, CA
Basak Eraslan
5Genentech, South San Francisco, CA
Alexander Gusev
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
7Division of Genetics, Brigham and Women’s Hospital, Boston, MA
Aviv Regev
2Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA
5Genentech, South San Francisco, CA
Brian Cleary
8Faculty of Computing and Data Sciences, Boston University, Boston, MA
9Department of Biology, Boston University, Boston, MA
10Department of Biomedical Engineering, Boston University, Boston, MA
11Program in Bioinformatics, Boston University, Boston, MA
12Biological Design Center, Boston University, Boston, MA
Article usage
Posted January 23, 2023.
Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations
Douglas Yao, Loic Binan, Jon Bezney, Brooke Simonton, Jahanara Freedman, Chris J. Frangieh, Kushal Dey, Kathryn Geiger-Schuller, Basak Eraslan, Alexander Gusev, Aviv Regev, Brian Cleary
bioRxiv 2023.01.23.525200; doi: https://doi.org/10.1101/2023.01.23.525200
Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations
Douglas Yao, Loic Binan, Jon Bezney, Brooke Simonton, Jahanara Freedman, Chris J. Frangieh, Kushal Dey, Kathryn Geiger-Schuller, Basak Eraslan, Alexander Gusev, Aviv Regev, Brian Cleary
bioRxiv 2023.01.23.525200; doi: https://doi.org/10.1101/2023.01.23.525200
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