A harmonized public resource of deeply sequenced diverse human genomes

Zan Koenig; Mary T. Yohannes; Lethukuthula L. Nkambule; Julia K. Goodrich; Heesu Ally Kim; Xuefang Zhao; Michael W. Wilson; Grace Tiao; Stephanie P. Hao; Nareh Sahakian; Katherine R. Chao; gnomAD Project Consortium; Heidi L. Rehm; Benjamin M. Neale; Michael E. Talkowski; Mark J. Daly; Harrison Brand; Konrad J. Karczewski; Elizabeth G. Atkinson; Alicia R. Martin

doi:10.1101/2023.01.23.525248

New Results

A harmonized public resource of deeply sequenced diverse human genomes

Zan Koenig, Mary T. Yohannes, Lethukuthula L. Nkambule, Julia K. Goodrich, Heesu Ally Kim, Xuefang Zhao, Michael W. Wilson, Grace Tiao, Stephanie P. Hao, Nareh Sahakian, Katherine R. Chao, gnomAD Project Consortium, View ORCID ProfileHeidi L. Rehm, View ORCID ProfileBenjamin M. Neale, Michael E. Talkowski, View ORCID ProfileMark J. Daly, Harrison Brand, Konrad J. Karczewski, View ORCID ProfileElizabeth G. Atkinson, View ORCID ProfileAlicia R. Martin

doi: https://doi.org/10.1101/2023.01.23.525248

Zan Koenig

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mary T. Yohannes

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lethukuthula L. Nkambule

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Julia K. Goodrich

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Heesu Ally Kim

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xuefang Zhao

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael W. Wilson

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Grace Tiao

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stephanie P. Hao

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nareh Sahakian

6Broad Genomics, The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA, 02141, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Katherine R. Chao

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Heidi L. Rehm

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Heidi L. Rehm

Benjamin M. Neale

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Benjamin M. Neale

Michael E. Talkowski

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark J. Daly

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

7Institute for Molecular Medicine Finland, Helsinki, Finland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mark J. Daly

Harrison Brand

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Konrad J. Karczewski

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elizabeth G. Atkinson

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

8Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Elizabeth G. Atkinson

Alicia R. Martin

1Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

3Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alicia R. Martin
For correspondence: armartin@broadinstitute.org

Abstract
Full Text
Info/History
Metrics
Supplementary material
Data/Code
Preview PDF

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

View the discussion thread.

PreviousNext

Posted August 10, 2023.

Download PDF

Supplementary Material

Data/Code

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following A harmonized public resource of deeply sequenced diverse human genomes

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

A harmonized public resource of deeply sequenced diverse human genomes

Zan Koenig, Mary T. Yohannes, Lethukuthula L. Nkambule, Julia K. Goodrich, Heesu Ally Kim, Xuefang Zhao, Michael W. Wilson, Grace Tiao, Stephanie P. Hao, Nareh Sahakian, Katherine R. Chao, gnomAD Project Consortium, Heidi L. Rehm, Benjamin M. Neale, Michael E. Talkowski, Mark J. Daly, Harrison Brand, Konrad J. Karczewski, Elizabeth G. Atkinson, Alicia R. Martin

bioRxiv 2023.01.23.525248; doi: https://doi.org/10.1101/2023.01.23.525248

Share This Article:

Citation Tools

A harmonized public resource of deeply sequenced diverse human genomes

Zan Koenig, Mary T. Yohannes, Lethukuthula L. Nkambule, Julia K. Goodrich, Heesu Ally Kim, Xuefang Zhao, Michael W. Wilson, Grace Tiao, Stephanie P. Hao, Nareh Sahakian, Katherine R. Chao, gnomAD Project Consortium, Heidi L. Rehm, Benjamin M. Neale, Michael E. Talkowski, Mark J. Daly, Harrison Brand, Konrad J. Karczewski, Elizabeth G. Atkinson, Alicia R. Martin

bioRxiv 2023.01.23.525248; doi: https://doi.org/10.1101/2023.01.23.525248

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Genomics

Subject Areas

All Articles

Animal Behavior and Cognition (4865)
Biochemistry (10821)
Bioengineering (8064)
Bioinformatics (27373)
Biophysics (14020)
Cancer Biology (11160)
Cell Biology (16099)
Clinical Trials (138)
Developmental Biology (8807)
Ecology (13329)
Epidemiology (2067)
Evolutionary Biology (17394)
Genetics (11704)
Genomics (15961)
Immunology (11057)
Microbiology (26154)
Molecular Biology (10679)
Neuroscience (56724)
Paleontology (422)
Pathology (1737)
Pharmacology and Toxicology (3012)
Physiology (4567)
Plant Biology (9665)
Scientific Communication and Education (1617)
Synthetic Biology (2699)
Systems Biology (6993)
Zoology (1513)