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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
View ORCID ProfileMartin S. Taylor, Connie Wu, Peter C. Fridy, Yasmeen Senussi, Wen-Chih Cheng, John Heaps, Kei Mori, Limor Cohen, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, View ORCID ProfileDavid R. Walt, View ORCID ProfileKathleen H. Burns
doi: https://doi.org/10.1101/2023.01.25.525462
Martin S. Taylor
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Connie Wu
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA
Peter C. Fridy
4Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA
Yasmeen Senussi
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA
Wen-Chih Cheng
5Department of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
John Heaps
5Department of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Kei Mori
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
6Healthcare Optics Research Laboratory, Canon U.S.A., Inc., Cambridge, MA, USA
Limor Cohen
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA
7Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
Kelly R. Molloy
8Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, USA
Brian T. Chait
8Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, USA
Michael Goggins
9Johns Hopkins University School of Medicine, Baltimore, MD, USA
Irun Bhan
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Joseph W. Franses
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Xiaoyu Yang
11Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Mary-Ellen Taplin
11Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Xinan Wang
12Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA
David C. Christiani
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
12Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA
Bruce E. Johnson
11Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Matthew Meyerson
11Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Ravindra Uppaluri
13Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Ann Marie Egloff
13Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Elyssa N. Denault
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Laura M. Spring
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Tian-Li Wang
9Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ie-Ming Shih
9Johns Hopkins University School of Medicine, Baltimore, MD, USA
Euihye Jung
14University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Kshitij S. Arora
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Lawrence R. Zukerberg
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Osman H. Yilmaz
15Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Gary Chi
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Bryanna L. Norden
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Yuhui Song
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Linda Nieman
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Aparna R. Parikh
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Matthew Strickland
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Tomas Mustelin
16Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA
George Eng
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
17The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Ömer H. Yilmaz
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
17The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Ursula A. Matulonis
11Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Steven J. Skates
18MGH Biostatistics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Bo R. Rueda
19Department of Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
Ronny Drapkin
14University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Samuel J. Klempner
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Vikram Deshpande
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
David T. Ting
10Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Michael P. Rout
4Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA
John LaCava
4Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA
20European Research Institute for the Biology of Ageing, University Medical Center Groningen, The Netherlands
David R. Walt
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA
Kathleen H. Burns
2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
5Department of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Article usage
Posted January 25, 2023.
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
Martin S. Taylor, Connie Wu, Peter C. Fridy, Yasmeen Senussi, Wen-Chih Cheng, John Heaps, Kei Mori, Limor Cohen, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, David R. Walt, Kathleen H. Burns
bioRxiv 2023.01.25.525462; doi: https://doi.org/10.1101/2023.01.25.525462
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
Martin S. Taylor, Connie Wu, Peter C. Fridy, Yasmeen Senussi, Wen-Chih Cheng, John Heaps, Kei Mori, Limor Cohen, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, David R. Walt, Kathleen H. Burns
bioRxiv 2023.01.25.525462; doi: https://doi.org/10.1101/2023.01.25.525462
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