Abstract
We present a spatial omics approach that merges and expands the capabilities of independently performed in situ assays on a single tissue section. Our spatial multimodal analysis combines histology, mass spectrometry imaging, and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular weight metabolites across tissue regions. We demonstrate the potential of our method using murine and human brain samples in the context of dopamine and Parkinson’s disease.
Competing Interest Statement
MV, RM, LL, and JL are scientific consultants for 10x Genomics Inc. The remaining authors declare no competing interests.
Copyright
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