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History
- January 31, 2023.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Author Information
- Ziyi Zhu1,†,
- Susannah Waxman2,†,
- Bo Wang1,2,3,
- Jacob Wallace2,
- Samantha E. Schmitt2,4,
- Elizabeth Tyler-Kabara2,5,6,
- Hiroshi Ishikawa7,8,
- Joel S. Schuman9,
- Matthew A. Smith1,2,4,10,
- Gadi Wollstein9 and
- Ian A. Sigal1,2,*
- 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
- 2Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA
- 3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 4Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
- 5Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA
- 6Department of Neurosurgery, University of Texas-Austin, Austin, TX, USA
- 7Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
- 8Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR, USA
- 9Department of Ophthalmology, NYU School of Medicine, New York, NY, USA
- 10Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA
- ↵*Correspondence: Ian A. Sigal, Ph.D., Laboratory of Ocular Biomechanics, Department of Ophthalmology, University of Pittsburgh, Eye & Ear Institute, 203 Lothrop St. Rm. 930, Pittsburgh, PA, USA. 15213 Phone: (412) 864-2220; fax: (412) 647-5880;, Email: ian{at}OcularBiomechanics.com, http://www.ocularbiomechanics.com
↵† Contributed equally to the manuscript and should be considered co-first authors.
Posted January 31, 2023.
In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal
