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A thin-film optogenetic visual prosthesis

Eric B Knudsen, Kara Zappitelli, Jennifer Brown, Jonathan Reeder, Kevin Sean Smith, Marat Rostov, Jaebin Choi, Amy Rochford, Nate Slager, Satoru K Miura, Kyle Rodgers, Ansel Reed, Yonatan R Lewis Israeli, Seton Shiraga, Kyung Jin Seo, Corey Wolin, Paul Dawson, Mohamed Eltaeb, Arvind Dasgupta, Paul Chong, Seleipiri Charles, Jay M. Stewart, Ruwan A Silva, Tyson Kim, Yifan Kong, Alan R Mardinly, Max Hodak
doi: https://doi.org/10.1101/2023.01.31.526482
Eric B Knudsen
1Science Corporation, Alameda CA, USA
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Kara Zappitelli
1Science Corporation, Alameda CA, USA
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Jennifer Brown
1Science Corporation, Alameda CA, USA
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Jonathan Reeder
1Science Corporation, Alameda CA, USA
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Kevin Sean Smith
1Science Corporation, Alameda CA, USA
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Marat Rostov
1Science Corporation, Alameda CA, USA
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Jaebin Choi
1Science Corporation, Alameda CA, USA
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Amy Rochford
1Science Corporation, Alameda CA, USA
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Nate Slager
1Science Corporation, Alameda CA, USA
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Satoru K Miura
1Science Corporation, Alameda CA, USA
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Kyle Rodgers
1Science Corporation, Alameda CA, USA
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Ansel Reed
1Science Corporation, Alameda CA, USA
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Yonatan R Lewis Israeli
1Science Corporation, Alameda CA, USA
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Seton Shiraga
1Science Corporation, Alameda CA, USA
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Kyung Jin Seo
1Science Corporation, Alameda CA, USA
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Corey Wolin
1Science Corporation, Alameda CA, USA
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Paul Dawson
1Science Corporation, Alameda CA, USA
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Mohamed Eltaeb
1Science Corporation, Alameda CA, USA
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Arvind Dasgupta
1Science Corporation, Alameda CA, USA
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Paul Chong
1Science Corporation, Alameda CA, USA
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Seleipiri Charles
1Science Corporation, Alameda CA, USA
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Jay M. Stewart
2Department of Ophthalmology, University of California, San Francisco, CA, USA
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Ruwan A Silva
3Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA
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Tyson Kim
2Department of Ophthalmology, University of California, San Francisco, CA, USA
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Yifan Kong
1Science Corporation, Alameda CA, USA
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Alan R Mardinly
1Science Corporation, Alameda CA, USA
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  • For correspondence: alanm@science.xyz
Max Hodak
1Science Corporation, Alameda CA, USA
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Abstract

Retinitis pigmentosa and macular degeneration lead to photoreceptor death and loss of visual perception. Despite recent progress, restorative technologies for photoreceptor degeneration remain largely unavailable. Here, we describe a novel optogenetic visual prosthesis (FlexLED) based on a combination of a thin-film retinal display and optogenetic activation of retinal ganglion cells (RGCs). The FlexLED implant is a 30 µm thin, flexible, wireless µLED display with 8,192 pixels, each with an emission area of 66 µm2. The display is affixed to the retinal surface, and the electronics package is mounted under the conjunctiva in the form factor of a conventional glaucoma drainage implant. In a rabbit model of photoreceptor degeneration, optical stimulation of the retina using the FlexLED elicits activity in visual cortex. This technology is readily scalable to hundreds of thousands of pixels, providing a route towards an implantable optogenetic visual prosthesis capable of generating vision by stimulating RGCs at near-cellular resolution.

Competing Interest Statement

All authors have a financial interest in Science Corporation

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 03, 2023.
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A thin-film optogenetic visual prosthesis
Eric B Knudsen, Kara Zappitelli, Jennifer Brown, Jonathan Reeder, Kevin Sean Smith, Marat Rostov, Jaebin Choi, Amy Rochford, Nate Slager, Satoru K Miura, Kyle Rodgers, Ansel Reed, Yonatan R Lewis Israeli, Seton Shiraga, Kyung Jin Seo, Corey Wolin, Paul Dawson, Mohamed Eltaeb, Arvind Dasgupta, Paul Chong, Seleipiri Charles, Jay M. Stewart, Ruwan A Silva, Tyson Kim, Yifan Kong, Alan R Mardinly, Max Hodak
bioRxiv 2023.01.31.526482; doi: https://doi.org/10.1101/2023.01.31.526482
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A thin-film optogenetic visual prosthesis
Eric B Knudsen, Kara Zappitelli, Jennifer Brown, Jonathan Reeder, Kevin Sean Smith, Marat Rostov, Jaebin Choi, Amy Rochford, Nate Slager, Satoru K Miura, Kyle Rodgers, Ansel Reed, Yonatan R Lewis Israeli, Seton Shiraga, Kyung Jin Seo, Corey Wolin, Paul Dawson, Mohamed Eltaeb, Arvind Dasgupta, Paul Chong, Seleipiri Charles, Jay M. Stewart, Ruwan A Silva, Tyson Kim, Yifan Kong, Alan R Mardinly, Max Hodak
bioRxiv 2023.01.31.526482; doi: https://doi.org/10.1101/2023.01.31.526482

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