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SARS-CoV-2 NSP5 Antagonizes the MHC II Antigen Presentation Pathway by Hijacking Histone Deacetylase 2

Nima Taefehshokr, Alex Lac, Angela M Vrieze, Brandon H Dickson, Peter N Guo, Catherine Jung, Eoin N Blythe, Corby Fink, Gregory A Dekaban, View ORCID ProfileBryan Heit
doi: https://doi.org/10.1101/2023.02.10.528032
Nima Taefehshokr
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Alex Lac
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Angela M Vrieze
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Brandon H Dickson
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Peter N Guo
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Catherine Jung
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
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Eoin N Blythe
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
2Robarts Research Institute, London, Ontario, Canada, N6A 3K7
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Corby Fink
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
2Robarts Research Institute, London, Ontario, Canada, N6A 3K7
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Gregory A Dekaban
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
2Robarts Research Institute, London, Ontario, Canada, N6A 3K7
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Bryan Heit
1Department of Microbiology and Immunology, and the Western Infection, Immunity and Inflammation Centre, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
2Robarts Research Institute, London, Ontario, Canada, N6A 3K7
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  • ORCID record for Bryan Heit
  • For correspondence: bheit@uwo.ca
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  • Supplemental Tables 1 & 2, Supplemental Figures S1-S5[supplements/528032_file03.pdf]
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Posted February 10, 2023.
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SARS-CoV-2 NSP5 Antagonizes the MHC II Antigen Presentation Pathway by Hijacking Histone Deacetylase 2
Nima Taefehshokr, Alex Lac, Angela M Vrieze, Brandon H Dickson, Peter N Guo, Catherine Jung, Eoin N Blythe, Corby Fink, Gregory A Dekaban, Bryan Heit
bioRxiv 2023.02.10.528032; doi: https://doi.org/10.1101/2023.02.10.528032
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SARS-CoV-2 NSP5 Antagonizes the MHC II Antigen Presentation Pathway by Hijacking Histone Deacetylase 2
Nima Taefehshokr, Alex Lac, Angela M Vrieze, Brandon H Dickson, Peter N Guo, Catherine Jung, Eoin N Blythe, Corby Fink, Gregory A Dekaban, Bryan Heit
bioRxiv 2023.02.10.528032; doi: https://doi.org/10.1101/2023.02.10.528032

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