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Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection
Louise Tzung-Harn Hsieh, Belinda S. Hall, Jane Newcombe, Tom A. Mendum, Sonia Santana-Varela, Yagnesh Umrania, Michael J. Deery, Wei Q. Shi, View ORCID ProfileJosué Diaz-Delgado, Francisco J. Salguero, View ORCID ProfileRachel E Simmonds
doi: https://doi.org/10.1101/2023.02.21.529382
Louise Tzung-Harn Hsieh
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
Belinda S. Hall
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
Jane Newcombe
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
Tom A. Mendum
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
Sonia Santana-Varela
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
Yagnesh Umrania
2Cambridge Centre for Proteomics, University of Cambridge, Cambridge, UK
Michael J. Deery
2Cambridge Centre for Proteomics, University of Cambridge, Cambridge, UK
Wei Q. Shi
3Department of Chemistry, Ball State University, Muncie, IN 47306, USA
Josué Diaz-Delgado
4Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA
Francisco J. Salguero
5United Kingdom Health Security Agency. UKHSA-Porton Down, Salisbury, U.K
Rachel E Simmonds
1Dept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey
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Posted October 01, 2024.
Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection
Louise Tzung-Harn Hsieh, Belinda S. Hall, Jane Newcombe, Tom A. Mendum, Sonia Santana-Varela, Yagnesh Umrania, Michael J. Deery, Wei Q. Shi, Josué Diaz-Delgado, Francisco J. Salguero, Rachel E Simmonds
bioRxiv 2023.02.21.529382; doi: https://doi.org/10.1101/2023.02.21.529382
Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection
Louise Tzung-Harn Hsieh, Belinda S. Hall, Jane Newcombe, Tom A. Mendum, Sonia Santana-Varela, Yagnesh Umrania, Michael J. Deery, Wei Q. Shi, Josué Diaz-Delgado, Francisco J. Salguero, Rachel E Simmonds
bioRxiv 2023.02.21.529382; doi: https://doi.org/10.1101/2023.02.21.529382
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