O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

Duc T. Huynh; Jimin Hu; Jordan R. Schneider; Kalina N. Tsolova; Erik J. Soderblom; Abigail J. Watson; Jen-Tsan Chi; Chantell S. Evans; Michael Boyce

doi:10.1101/2023.02.22.529563

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O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

View ORCID ProfileDuc T. Huynh, Jimin Hu, Jordan R. Schneider, View ORCID ProfileKalina N. Tsolova, Erik J. Soderblom, Abigail J. Watson, View ORCID ProfileJen-Tsan Chi, View ORCID ProfileChantell S. Evans, View ORCID ProfileMichael Boyce

doi: https://doi.org/10.1101/2023.02.22.529563

Duc T. Huynh

1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

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Jimin Hu

1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

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Jordan R. Schneider

2Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA

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Kalina N. Tsolova

1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

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Erik J. Soderblom

3Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC 27710, USA

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Abigail J. Watson

1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

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Jen-Tsan Chi

2Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA

4Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA

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Chantell S. Evans

2Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA

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Michael Boyce

1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

2Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA

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For correspondence: michael.boyce@duke.edu

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O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

Duc T. Huynh, Jimin Hu, Jordan R. Schneider, Kalina N. Tsolova, Erik J. Soderblom, Abigail J. Watson, Jen-Tsan Chi, Chantell S. Evans, Michael Boyce

bioRxiv 2023.02.22.529563; doi: https://doi.org/10.1101/2023.02.22.529563

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O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

Duc T. Huynh, Jimin Hu, Jordan R. Schneider, Kalina N. Tsolova, Erik J. Soderblom, Abigail J. Watson, Jen-Tsan Chi, Chantell S. Evans, Michael Boyce

bioRxiv 2023.02.22.529563; doi: https://doi.org/10.1101/2023.02.22.529563

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