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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

View ORCID ProfileLeonhard Waschke, Fabian Kamp, Evi van den Elzen, Suresh Krishna, Ulman Lindenberger, View ORCID ProfileUeli Rutishauser, Douglas D. Garrett
doi: https://doi.org/10.1101/2023.02.23.529684
Leonhard Waschke
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, 14195 Berlin, Germany
2Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
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  • ORCID record for Leonhard Waschke
Fabian Kamp
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, 14195 Berlin, Germany
2Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
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Evi van den Elzen
3Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands
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Suresh Krishna
4Department of Physiology, McGill University, Montreal, Canada
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Ulman Lindenberger
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, 14195 Berlin, Germany
2Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
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Ueli Rutishauser
5Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
6Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
7Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA, USA
8Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA
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Douglas D. Garrett
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, 14195 Berlin, Germany
2Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
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  • For correspondence: garrett@mpib-berlin.mpg.de
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Abstract

During memory formation, the hippocampus is presumed to represent the “content” of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 23, 2023.
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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans
Leonhard Waschke, Fabian Kamp, Evi van den Elzen, Suresh Krishna, Ulman Lindenberger, Ueli Rutishauser, Douglas D. Garrett
bioRxiv 2023.02.23.529684; doi: https://doi.org/10.1101/2023.02.23.529684
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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans
Leonhard Waschke, Fabian Kamp, Evi van den Elzen, Suresh Krishna, Ulman Lindenberger, Ueli Rutishauser, Douglas D. Garrett
bioRxiv 2023.02.23.529684; doi: https://doi.org/10.1101/2023.02.23.529684

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