Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage

Saed Abbasi; Miki Matsui-Masai; Akimasa Hayashi; Theofilus A. Tockary; Shiro Akinaga; Kazunori Kataoka; Satoshi Uchida

doi:10.1101/2023.02.27.530188

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Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage

Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Kazunori Kataoka, View ORCID ProfileSatoshi Uchida

doi: https://doi.org/10.1101/2023.02.27.530188

Saed Abbasi

1Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

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Miki Matsui-Masai

2Department of Research, NanoCarrier Co., Ltd., 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

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Akimasa Hayashi

3Department of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan

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Theofilus A. Tockary

1Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

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Shiro Akinaga

2Department of Research, NanoCarrier Co., Ltd., 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

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Kazunori Kataoka

1Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

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For correspondence: kkataoka@g.ecc.u-tokyo.ac.jp uchida.anme@tmd.ac.jp

Satoshi Uchida

1Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

4Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima Bunkyo-ku Tokyo 113-8510 Japan

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ORCID record for Satoshi Uchida
For correspondence: kkataoka@g.ecc.u-tokyo.ac.jp uchida.anme@tmd.ac.jp

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Posted February 27, 2023.

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Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage

Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Kazunori Kataoka, Satoshi Uchida

bioRxiv 2023.02.27.530188; doi: https://doi.org/10.1101/2023.02.27.530188

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Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage

Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Kazunori Kataoka, Satoshi Uchida

bioRxiv 2023.02.27.530188; doi: https://doi.org/10.1101/2023.02.27.530188

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