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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures

Steve Yoon, Eddy Anaya, Jaiprasath Sachithanandham, View ORCID ProfileBenjamin Pinsky, View ORCID ProfileDavid Sullivan, View ORCID ProfileHeba H. Mostafa, View ORCID ProfileAndrew Pekosz
doi: https://doi.org/10.1101/2023.03.03.531067
Steve Yoon
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
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Eddy Anaya
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
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Jaiprasath Sachithanandham
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
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Benjamin Pinsky
3Department of Pathology, School of Medicine, Stanford University, Stanford, California, USA
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David Sullivan
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
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Heba H. Mostafa
2Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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  • ORCID record for Heba H. Mostafa
Andrew Pekosz
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
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  • For correspondence: apekosz1@jhu.edu
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Article Information

doi 
https://doi.org/10.1101/2023.03.03.531067
History 
  • March 6, 2023.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Steve Yoon1,
  2. Eddy Anaya1,
  3. Jaiprasath Sachithanandham1,
  4. Benjamin Pinsky3,
  5. David Sullivan1,
  6. Heba H. Mostafa2 and
  7. Andrew Pekosz1,*
  1. 1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
  2. 2Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
  3. 3Department of Pathology, School of Medicine, Stanford University, Stanford, California, USA
  1. ↵*Corresponding author: apekosz1{at}jhu.edu
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Posted March 06, 2023.
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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures
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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures
Steve Yoon, Eddy Anaya, Jaiprasath Sachithanandham, Benjamin Pinsky, David Sullivan, Heba H. Mostafa, Andrew Pekosz
bioRxiv 2023.03.03.531067; doi: https://doi.org/10.1101/2023.03.03.531067
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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures
Steve Yoon, Eddy Anaya, Jaiprasath Sachithanandham, Benjamin Pinsky, David Sullivan, Heba H. Mostafa, Andrew Pekosz
bioRxiv 2023.03.03.531067; doi: https://doi.org/10.1101/2023.03.03.531067

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