Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures

Steve Yoon; Eddy Anaya; Jaiprasath Sachithanandham; Benjamin Pinsky; David Sullivan; Heba H. Mostafa; Andrew Pekosz

doi:10.1101/2023.03.03.531067

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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures

Steve Yoon, Eddy Anaya, Jaiprasath Sachithanandham, View ORCID ProfileBenjamin Pinsky, View ORCID ProfileDavid Sullivan, View ORCID ProfileHeba H. Mostafa, View ORCID ProfileAndrew Pekosz

doi: https://doi.org/10.1101/2023.03.03.531067

Steve Yoon

1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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Eddy Anaya

1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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Jaiprasath Sachithanandham

1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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Benjamin Pinsky

3Department of Pathology, School of Medicine, Stanford University, Stanford, California, USA

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ORCID record for Benjamin Pinsky

David Sullivan

1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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Heba H. Mostafa

2Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

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Andrew Pekosz

1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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For correspondence: apekosz1@jhu.edu

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Posted March 06, 2023.

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Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures