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High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

View ORCID ProfileZhijie Dong, View ORCID ProfileShuangliang Li, Xiaoyu Duan, View ORCID ProfileMatthew R. Lowerison, View ORCID ProfileChengwu Huang, View ORCID ProfileQi You, View ORCID ProfileShigao Chen, Jun Zou, View ORCID ProfilePengfei Song
doi: https://doi.org/10.1101/2023.03.07.531439
Zhijie Dong
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
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Shuangliang Li
3Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX
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Xiaoyu Duan
3Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX
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Matthew R. Lowerison
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
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Chengwu Huang
4Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN
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Qi You
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
5Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL
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Shigao Chen
4Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN
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Jun Zou
3Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX
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Pengfei Song
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
5Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL
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  • For correspondence: songp@illinois.edu
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Abstract

3-D ultrasound imaging has many advantages over 2-D imaging such as more comprehensive tissue evaluation and less operator dependence. Although many 3-D ultrasound imaging techniques have been developed in the last several decades, a low-cost and accessible solution with high imaging volume rate and imaging quality remains elusive. Recently we proposed a new, high volume rate 3-D ultrasound imaging technique: Fast Acoustic Steering via Tilting Electromechanical Reflectors (FASTER), which uses a water-immersible and fast-tilting acoustic reflector to steer ultrafast plane waves in the elevational direction to achieve high volume rate 3-D ultrasound imaging with conventional 1-D array transducers. However, the initial implementation of FASTER imaging only involves a single fast-tilting acoustic reflector, which is inconvenient to use because the probe cannot be held in the regular upright position. Also, conventional FASTER imaging can only be performed inside a water tank because of the necessity of using water for acoustic conduction. To address these limitations of conventional FASTER, here we developed a novel ultrasound probe clip-on device that encloses a fast-tilting reflector, a redirecting reflector, and an acoustic wave conduction medium. The new FASTER 3-D imaging device can be easily attached to or removed from clinical ultrasound transducers, allowing rapid transformation from 2-D to 3-D ultrasound imaging. In vitro B-mode imaging studies demonstrated that the proposed method provided comparable imaging quality (e.g., spatial resolution and contrast-to-noise ratio) to conventional, mechanical-translation-based 3-D imaging while providing a much faster 3-D volume rate (e.g., 300 Hz vs ∼10 Hz). In addition to B-mode imaging, we also demonstrated 3-D power Doppler imaging and 3-D super-resolution ultrasound localization microscopy with the newly developed FASTER device. An in vivo imaging study showed that the FASTER device could clearly visualize the 3-D anatomy of the basilic vein of a healthy volunteer, and customized beamforming was implemented to accommodate the speed of sound difference between the acoustic medium and the imaging object (e.g., soft tissue). These results suggest that the newly developed redirecting reflector and the clip-on device could overcome key hurdles for future clinical translation of the FASTER 3-D imaging technology.

Competing Interest Statement

The authors have declared no competing interest.

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Posted March 09, 2023.
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High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors
Zhijie Dong, Shuangliang Li, Xiaoyu Duan, Matthew R. Lowerison, Chengwu Huang, Qi You, Shigao Chen, Jun Zou, Pengfei Song
bioRxiv 2023.03.07.531439; doi: https://doi.org/10.1101/2023.03.07.531439
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High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors
Zhijie Dong, Shuangliang Li, Xiaoyu Duan, Matthew R. Lowerison, Chengwu Huang, Qi You, Shigao Chen, Jun Zou, Pengfei Song
bioRxiv 2023.03.07.531439; doi: https://doi.org/10.1101/2023.03.07.531439

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