Gestational exposure to unmethylated CpG oligonucleotides dysregulates placental molecular clock network and fetoplacental growth dynamics, and disrupts maternal blood pressure circadian rhythms in rats

Jessica L. Bradshaw; Spencer C. Cushen; Contessa A. Ricci; Selina M. Tucker; Jennifer J. Gardner; Joel T. Little; Oluwatobiloba Osikoya; Styliani Goulopoulou

doi:10.1101/2023.03.14.532649

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Gestational exposure to unmethylated CpG oligonucleotides dysregulates placental molecular clock network and fetoplacental growth dynamics, and disrupts maternal blood pressure circadian rhythms in rats

View ORCID ProfileJessica L. Bradshaw, View ORCID ProfileSpencer C. Cushen, View ORCID ProfileContessa A. Ricci, View ORCID ProfileSelina M. Tucker, View ORCID ProfileJennifer J. Gardner, Joel T. Little, View ORCID ProfileOluwatobiloba Osikoya, View ORCID ProfileStyliani Goulopoulou

doi: https://doi.org/10.1101/2023.03.14.532649

Jessica L. Bradshaw

1Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, USA

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Spencer C. Cushen

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

3Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Contessa A. Ricci

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Selina M. Tucker

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Jennifer J. Gardner

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Joel T. Little

1Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Oluwatobiloba Osikoya

2Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA

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Styliani Goulopoulou

4Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA

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For correspondence: sgoulopoulou@llu.edu

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Posted March 15, 2023.

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Gestational exposure to unmethylated CpG oligonucleotides dysregulates placental molecular clock network and fetoplacental growth dynamics, and disrupts maternal blood pressure circadian rhythms in rats

Jessica L. Bradshaw, Spencer C. Cushen, Contessa A. Ricci, Selina M. Tucker, Jennifer J. Gardner, Joel T. Little, Oluwatobiloba Osikoya, Styliani Goulopoulou

bioRxiv 2023.03.14.532649; doi: https://doi.org/10.1101/2023.03.14.532649

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Jessica L. Bradshaw, Spencer C. Cushen, Contessa A. Ricci, Selina M. Tucker, Jennifer J. Gardner, Joel T. Little, Oluwatobiloba Osikoya, Styliani Goulopoulou

bioRxiv 2023.03.14.532649; doi: https://doi.org/10.1101/2023.03.14.532649

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