Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Sarah M. Mohr; Rafael Dai Pra; Maryann P. Platt; Viktor V. Feketa; Marya Shanabrough; Luis Varela; Ashley Kristant; Haoran Cao; Dana K. Merriman; Tamas L. Horvath; Sviatoslav N. Bagriantsev; Elena O. Gracheva

doi:10.1101/2023.03.15.532843

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Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Sarah M. Mohr, Rafael Dai Pra, Maryann P. Platt, Viktor V. Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K. Merriman, Tamas L. Horvath, View ORCID ProfileSviatoslav N. Bagriantsev, View ORCID ProfileElena O. Gracheva

doi: https://doi.org/10.1101/2023.03.15.532843

Sarah M. Mohr

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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Rafael Dai Pra

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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Maryann P. Platt

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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Viktor V. Feketa

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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Marya Shanabrough

4Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA

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Luis Varela

4Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA

5Achucarro Basque Center for Neuroscience, Leioa, Spain 48940

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Ashley Kristant

4Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA

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Haoran Cao

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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Dana K. Merriman

6Department of Biology, University of Wisconsin-Oshkosh, 800 Algoma Boulevard, Oshkosh, WI 54901, USA

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Tamas L. Horvath

4Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA

5Achucarro Basque Center for Neuroscience, Leioa, Spain 48940

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Sviatoslav N. Bagriantsev

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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ORCID record for Sviatoslav N. Bagriantsev
For correspondence: slav.bagriantsev@yale.edu elena.gracheva@yale.edu

Elena O. Gracheva

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

2Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

3Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA

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ORCID record for Elena O. Gracheva
For correspondence: slav.bagriantsev@yale.edu elena.gracheva@yale.edu

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Posted March 16, 2023.

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Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Sarah M. Mohr, Rafael Dai Pra, Maryann P. Platt, Viktor V. Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K. Merriman, Tamas L. Horvath, Sviatoslav N. Bagriantsev, Elena O. Gracheva

bioRxiv 2023.03.15.532843; doi: https://doi.org/10.1101/2023.03.15.532843

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