New Results
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, View ORCID ProfileMasamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, View ORCID ProfileYosuke Tanaka, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, View ORCID ProfileAtsushi Iwama, Toshio Suda, View ORCID ProfileKeiyo Takubo
doi: https://doi.org/10.1101/2023.03.16.532898
Shintaro Watanuki
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
2Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
Hiroshi Kobayashi
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Yuki Sugiura
3Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan
4Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
Masamichi Yamamoto
5Department of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan
Daiki Karigane
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
2Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
Kohei Shiroshita
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
2Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
Yuriko Sorimachi
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
6Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo 162-8480, Japan
Shuhei Koide
7Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The University of Tokyo, Tokyo 108-8639, Japan
Motohiko Oshima
7Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The University of Tokyo, Tokyo 108-8639, Japan
Akira Nishiyama
9Department of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan
Koichi Murakami
9Department of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan
10Advanced Medical Research Center, Yokohama City University, Kanagawa 236-0004, Japan
Miho Haraguchi
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Shinpei Tamaki
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Takehiro Yamamoto
3Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan
Tomohiro Yabushita
8Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Yosuke Tanaka
8Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
11International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan
Hiroaki Honda
12Field of Human Disease Models, Major in Advanced Life Sciences and Medicine, Institute of Laboratory Animals, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Shinichiro Okamoto
2Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
Nobuhito Goda
6Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo 162-8480, Japan
Tomohiko Tamura
9Department of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan
10Advanced Medical Research Center, Yokohama City University, Kanagawa 236-0004, Japan
Ayako Nakamura-Ishizu
13Department of Microscopic and Developmental Anatomy, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Makoto Suematsu
3Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan
14Live Imaging Center, Central Institute for Experimental Animals, Kanagawa 210-0821, Japan
Atsushi Iwama
7Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The University of Tokyo, Tokyo 108-8639, Japan
Toshio Suda
11International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan
15Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Keiyo Takubo
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
16Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Tokyo 100-0004, Japan
Posted March 18, 2023.
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, Yosuke Tanaka, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, Atsushi Iwama, Toshio Suda, Keiyo Takubo
bioRxiv 2023.03.16.532898; doi: https://doi.org/10.1101/2023.03.16.532898
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, Yosuke Tanaka, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, Atsushi Iwama, Toshio Suda, Keiyo Takubo
bioRxiv 2023.03.16.532898; doi: https://doi.org/10.1101/2023.03.16.532898
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