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Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

View ORCID ProfileGeoffroy Delamare, View ORCID ProfileYosif Zaki, View ORCID ProfileDenise J Cai, View ORCID ProfileClaudia Clopath
doi: https://doi.org/10.1101/2023.03.16.532958
Geoffroy Delamare
1Bioengineering Department, Imperial College London, London SW7 2AZ, UK
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  • For correspondence: g.delamare21@imperial.ac.uk
Yosif Zaki
2Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, New York, 10029, United States
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Denise J Cai
2Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, New York, 10029, United States
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Claudia Clopath
1Bioengineering Department, Imperial College London, London SW7 2AZ, UK
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Abstract

Representational drift refers to the dynamic nature of neural representations in the brain despite the behavior being seemingly stable. Although drift has been observed in many different brain regions, the mechanisms underlying it are not known. Since intrinsic neural excitability is suggested to play a key role in regulating memory allocation, fluctuations of excitability could bias the reactivation of previously stored memory ensembles and therefore act as a motor for drift. Here, we propose a rate-based plastic recurrent neural network with slow fluctuations of intrinsic excitability. We first show that subsequent reactivations of a neural ensemble can lead to drift of this ensemble. The model predicts that drift is induced by co-activation of previously active neurons along with neurons with high excitability which leads to remodelling of the recurrent weights. Consistent with previous experimental works, the drifting ensemble is informative about its temporal history. Crucially, we show that the gradual nature of the drift is necessary for decoding temporal information from the activity of the ensemble. Finally, we show that the memory is preserved and can be decoded by an output neuron having plastic synapses with the main region.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 17, 2023.
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Drift of neural ensembles driven by slow fluctuations of intrinsic excitability
Geoffroy Delamare, Yosif Zaki, Denise J Cai, Claudia Clopath
bioRxiv 2023.03.16.532958; doi: https://doi.org/10.1101/2023.03.16.532958
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Drift of neural ensembles driven by slow fluctuations of intrinsic excitability
Geoffroy Delamare, Yosif Zaki, Denise J Cai, Claudia Clopath
bioRxiv 2023.03.16.532958; doi: https://doi.org/10.1101/2023.03.16.532958

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