Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

Timothy E. Hoffman; Chen Yang; Varuna Nangia; C. Ryland Ill; Sabrina L. Spencer

doi:10.1101/2023.03.17.533211

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Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

View ORCID ProfileTimothy E. Hoffman, Chen Yang, Varuna Nangia, C. Ryland Ill, Sabrina L. Spencer

doi: https://doi.org/10.1101/2023.03.17.533211

Timothy E. Hoffman

1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO, USA

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Chen Yang

1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO, USA

2Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA

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Varuna Nangia

1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO, USA

3Medical Scientist Training Program, University of Colorado-Anschutz Medical School, Aurora, CO, USA

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C. Ryland Ill

1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO, USA

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Sabrina L. Spencer

1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO, USA

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For correspondence: [email protected]

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Posted March 21, 2023.

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Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

Timothy E. Hoffman, Chen Yang, Varuna Nangia, C. Ryland Ill, Sabrina L. Spencer

bioRxiv 2023.03.17.533211; doi: https://doi.org/10.1101/2023.03.17.533211

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Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

Timothy E. Hoffman, Chen Yang, Varuna Nangia, C. Ryland Ill, Sabrina L. Spencer

bioRxiv 2023.03.17.533211; doi: https://doi.org/10.1101/2023.03.17.533211

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