Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Yi Sun; Michael C. Young; Claire H. Woodward; Julia N. Danon; Hau Truong; Sagar Gupta; Trenton J. Winters; George Burslem; Nikolaos G. Sgourakis

doi:10.1101/2023.03.18.533266

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Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Yi Sun, Michael C. Young, Claire H. Woodward, Julia N. Danon, Hau Truong, Sagar Gupta, Trenton J. Winters, View ORCID ProfileGeorge Burslem, View ORCID ProfileNikolaos G. Sgourakis

doi: https://doi.org/10.1101/2023.03.18.533266

Yi Sun

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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Michael C. Young

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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Claire H. Woodward

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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Julia N. Danon

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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Hau Truong

3Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine

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Sagar Gupta

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

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Trenton J. Winters

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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George Burslem

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

3Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine

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ORCID record for George Burslem

Nikolaos G. Sgourakis

1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

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ORCID record for Nikolaos G. Sgourakis
For correspondence: Nikolaos.Sgourakis@Pennmedicine.upenn.edu

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Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Yi Sun, Michael C. Young, Claire H. Woodward, Julia N. Danon, Hau Truong, Sagar Gupta, Trenton J. Winters, George Burslem, Nikolaos G. Sgourakis

bioRxiv 2023.03.18.533266; doi: https://doi.org/10.1101/2023.03.18.533266

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Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Yi Sun, Michael C. Young, Claire H. Woodward, Julia N. Danon, Hau Truong, Sagar Gupta, Trenton J. Winters, George Burslem, Nikolaos G. Sgourakis

bioRxiv 2023.03.18.533266; doi: https://doi.org/10.1101/2023.03.18.533266

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