Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

Luke C. Bartelt; Pawel M. Switonski; Juliana Carvalho; Lisa A. Duvick; Daniel R. Scoles; Stefan M. Pulst; Harry T. Orr; Court Hull; Craig B. Lowe; Albert R. La Spada

doi:10.1101/2023.03.19.533345

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Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

Luke C. Bartelt, Pawel M. Switonski, Juliana Carvalho, Lisa A. Duvick, Daniel R. Scoles, Stefan M. Pulst, Harry T. Orr, Court Hull, Craig B. Lowe, Albert R. La Spada

doi: https://doi.org/10.1101/2023.03.19.533345

Luke C. Bartelt

1University Program in Genetics & Genomics, Duke University School of Medicine, Durham, NC 27710, USA

2Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine; Irvine, CA 92697, USA

3Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA

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Pawel M. Switonski

4Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland

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Juliana Carvalho

3Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA

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Lisa A. Duvick

5Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA

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Daniel R. Scoles

6Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA

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Stefan M. Pulst

6Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA

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Harry T. Orr

5Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA

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Court Hull

7Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA

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Craig B. Lowe

3Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA

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For correspondence: craig.lowe@duke.edu alaspada@uci.edu

Albert R. La Spada

2Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine; Irvine, CA 92697, USA

8Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA

9UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA 92697, USA

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For correspondence: craig.lowe@duke.edu alaspada@uci.edu

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Posted March 20, 2023.

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Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

Luke C. Bartelt, Pawel M. Switonski, Juliana Carvalho, Lisa A. Duvick, Daniel R. Scoles, Stefan M. Pulst, Harry T. Orr, Court Hull, Craig B. Lowe, Albert R. La Spada

bioRxiv 2023.03.19.533345; doi: https://doi.org/10.1101/2023.03.19.533345

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Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

Luke C. Bartelt, Pawel M. Switonski, Juliana Carvalho, Lisa A. Duvick, Daniel R. Scoles, Stefan M. Pulst, Harry T. Orr, Court Hull, Craig B. Lowe, Albert R. La Spada

bioRxiv 2023.03.19.533345; doi: https://doi.org/10.1101/2023.03.19.533345

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